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In addition, genetic markers clearly indicate the possible course of development and the course of the disease, which allows us to act preventively, in order to soften the clinical picture.
This, for “Novosti”, says prof. Dr. Snezana Pajovic, director of the “Vinca” Institute of Nuclear Sciences, speaking about the research being carried out by researchers at the Laboratory of Radiobiology and Molecular Genetics of this institute. Through their research, our interlocutor points out, we contribute to new knowledge, which genetic parameters in patients are associated with a more serious clinical picture and thus define which people are more susceptible to developing complications.
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– Of course, it is necessary to include in the analysis all known risk factors so far for complications from covid, so that the risk assessment is as accurate as possible – he says. – The results of such research can significantly help to evaluate the use of existing medicines in the fight against kovid 19, and it is extremely important that Serbia has its place in creating new knowledge in this area.
He points out that Serbia does not have data on the detailed genetic structure of its population, and therefore is not in a position to use the existing databases, which many in the world are doing.
VERIFICATION OF DRUGS FROM SERBIA
THE RESULTS of the “Kovid target” project will allow the selection of approved, cheap and non-toxic drugs that will be ready for clinical trials before the end of the project or immediately after its completion.
– It is expected that the selected drugs can be used in the prevention and treatment of covid 19 in the next epidemic waves – says Snezana Pajovic. – The results of this project will be especially important for our pharmaceutical industry, as the medicines produced in Serbia will also be analyzed. The research reached the second preclinical phase: in cultured cells and animal models.
It emphasizes that only the “Vinca” Institute, in the whole of Serbia, has the capital equipment to perform this type of genetic analysis for our population.
– We also have knowledge for such research, as well as personnel trained for experimental work in each phase of the research – he points out.
The scientific research work of this project will last about 18 months and, as prof. Dr. Pajović, and the first results are expected eight to ten months after the start of the project.
Apart from this project, the “Vinča” researchers are also working on testing drugs against kovid 19, which are already in use, in cooperation with colleagues from Texas.
– The research to be carried out within this project is based on the innovative computing methodology developed at the “Vinca” Institute – says our interlocutor.
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She explains that the activity of existing drugs will be examined, examining the effect on the SARS-KoV-2 virus and its more aggressive mutant D614G.
– Since there are no experimental conditions for this test in our country, it will be carried out in cooperation with the National Laboratory for Preclinical Studies and the BSL3 National Laboratory of the Galveston Institute of the University of Texas, which is also the US Reference Laboratory. For the SARS-KoV-2 virus.
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