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Why do some people with coronavirus have no symptoms, while others become seriously ill, end up on a respirator, and even die? Is it one of the biggest mysteries of the pandemic? The answer is partly in the genes, that is, in the mutation of the five genes that are associated with the most serious forms. kovida 19revealed a scientific study conducted in the United Kingdom.
This finding provides new insight into where the immune system “fails” in the fight. virus, which can help establish new therapies to treat kovid. Researchers from the University of Edinburgh studied the DNA of 2,700 patients housed in 208 intensive care units in Britain and concluded that five genes related to the antiviral immune response and pneumonia play a key role in many severe cases.
– The IFNAR2, TYK2, OAS1, DPP9 and CR2 genes partly explain why some develop a very severe form of the disease, while others are not affected by the virus. We scanned the genes from each of the patients and then the genomes were compared to the DNA of healthy people to detect differences. Several were found: the first is in a gene called TYK2. Differences were also found in the DPP9 gene, which also plays a role in inflammation, as well as in the OAS gene. Variations in the IFNAR2 gene, which is linked to the interferon molecule, which helps to activate the immune system as soon as it detects an infection, have also been observed in intensive care patients. “Our results show which drugs should be at the top of the list for clinical trials,” said Kenneth Bailey, one of the leaders of the research published in the journal Nature, as reported by Reuters.
Genetics specialist and molecular biologist and physiologist Dr. Ivana Buzadzic told Kurir that such research is the basis for the development of personalized medicine, because each organism is different and, therefore, reacts differently.
– Before any therapy, a genetic investigation must be carried out, and only then will we know what the organism’s reaction will be. This type of research takes time and the goal is personalized medicine and pharmacogenetics, that is, individual therapy for each individual. Prevention should be done, so that even when complications occur, the body’s reaction is the best possible. If someone has serious health problems, they should react quickly and no treatment through Google or the advice of a neighbor is out of the question. In this case, geneticists should be listened to when all research is in question, and pharmacologists and immunologists for therapy, said Dr. Buzadzic.
Milika ashanin
Necovid capacities reduced to 30-40 percent
The director of the Serbian Clinical Center, Milika Ashanin, said yesterday that the opening of the Kovid hospital in Batajnica was a saving because all the capacities of the hospital were overloaded. He also pointed out that KCS employees are working on two tracks, in the kovid and nekovid section, which had to comply with the anti-pandemic measures. – First we have reduced the capacity of some works to 50 percent, and now we are at 30-40 percent. We are working to care for urgent and chronic patients who have reached urgent conditions, mostly cardiovascular, malignant diseases and complications of diabetes, he told RTS.
Snezana Pajovic
Predisposition to disease
The director of the Vinca Institute of Nuclear Sciences, Snezana Pajovic, recently said that the genetic profile of each one of us carries certain records in the genes, which determine if there is a greater or lesser predisposition to covid 19. Radiobiology and molecular genetics of that institute , and as Dr. Pajović added, genetic markers clearly indicate the possible course of disease development, allowing preventive action. The scientific research work of this project will last 18 months.
48 people died
In the homes of about 3,000 infected
In the last 24 hours, 16,886 citizens were tested for coronavirus in Serbia, of which 5,679 tested positive, while 48 people died, bringing the total number of deaths since the start of the epidemic in the country to 2,275. There are 318 patients on ventilators, while a total of 8,744 patients were hospitalized. Almost 3,000 people were infected in social protection institutions and homes for adults and the elderly: 2,057 users and 902 employees, announced the Ministry of Labor.
Jelena Pronić
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