With U.S. infections close to 5 million, Fauci says public expectations should temper COVID-19 vaccine


Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases for the last three decades and an expert on pandemics for the last four decades, has been optimistic about a vaccine arriving in late 2020 or early 2021, but he has also warned the public about their expectations for the effectiveness of each vaccine being developed.

“The chance that it’s 98% is not great, which means you should never abandon the approach to public health,” Fauci said in a recent live-streaming Q&A hosted by Brown University. “You have to think of a vaccine as a tool to get a pandemic to no longer be a pandemic, but to be something that is well controlled.”

“What I’m shooting is that we, with a vaccine and good public health measures, can bring it somewhere between really good control and elimination,” he told Abdullah Shihipar, a public health worker at Brown in the interview. “That’s what a fax machine will do, but it will not do it alone.”


‘The chance that it’s 98% is not great. Which means you should never abandon the approach of public health. ‘


– Anthony Fauci, Director of the National Institute of Allergy and Infectious Diseases

Fauci has said he hoped an early 2021 coronavirus vaccine could be developed, but has previously said it is unlikely a vaccine will deliver 100% immunity; he said the best realistic outcome, based on other faxes, would be 70% to 75% effective. The vaccine against measles, he said, is one of the most effective in providing 97% immunity.

Reviews of past studies have found that, on average, the flu vaccine is approximately 50% to 60% effective for healthy adults between 18 and 64 years old, according to a review of studies by the Mayo Clinic. “The vaccine can sometimes be less effective,” it said. “Even if the vaccine does not completely prevent the flu, it can reduce the severity of your illness.”

Fauci advocates for face masks, social distance and avoidance of bars and indoor spaces with crowds. “If we do those things – and I will repeat them until I’m exhausted – then those things work,” he said on Friday’s live stream. “If you have something that everyone needs to pull at the same time, if you have one weak switch in there that does not, it does not let you get to the endgame.”

Stephen Hahn, commissioner of the Food and Drug Administration, said last month that the agency would give a coronavirus green light vaccine as long as it is 50% effective. “We all want a vaccine tomorrow that is unrealistic, and we all want a vaccine that is 100% effective and unrealistic again. We said 50%. Hahn added, “That was a ridiculous floor considering the pandemic.”

As of Sunday, COVID-19 had infected at least 19.4 million people worldwide and just ashamed of 5 million in the US It had killed 727,111 people worldwide and at least 162,425 in the US The Dow Jones Industrial Index DJIA,
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Friday ended higher when investors rounded two waits for a fiscal stimulus; the COMP of Nasdaq Composite,
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refused.

Related: Feeling good about masks? Think again. Here’s how many lives can be saved if everyone wore a mask – starting today

In the absence of a vaccine, health experts say social distance and masks are the only alternative as “herd immunity” – where those who are immune protect the most vulnerable in the population – is not possible for coronavirus. This requires a high level of population immunity for COVID-19, the disease caused by the SARS-CoV-2 virus, and for the virus not to mutate.

“None of these seem to be operational at the moment,” Gregory Poland, who studies the immunogenetics of vaccines at the Mayo Clinic, told MarketWatch in April. “With impact, your herd immunity needs from 60% to 70%. With knives you need about 95%. With COVID-19, it’s somewhere in the middle, ‘he said.

“What we saw during the pandemic were a lot of preprints and press releases,” Hahn said in a separate interview with the medical journal JAMA. “We can not make a decision based on a preprint or a press release, and that is because we insist on looking at all raw clinical trial data.” Traditionally, such research goes through a peer-review process before publishing.


‘With influence, you need herd immunity from 60% to 70%. With knives you need about 95%. With COVID-19, it’s somewhere in the middle. ‘


– Gregory Poland, who researches the immunogenetics of vaccines at the Mayo Clinic

In the meantime, the public must continue to wear masks, authorities say. America’s COVID-19 death toll in the U.S. could reach nearly 300,000 as of Dec. 1, but consistent mask-wearing early today could save about 70,000 lives, according to projections released last week by the Institute for Health Metrics and Evaluation. the University of Washington’s School of Medicine.

“It seems that people wear masks and more often social distance, as infections increase, then people after a while as infections subside, stop and stop taking these measures to protect themselves and others, which of course leads to more infections,” HME director Christopher Murray said, “and the potentially deadly cycle begins again.”

In April – after two months of obfuscation over the effectiveness of face masks, in which New York City became the epicenter of the US pandemic, and one month after the WHO declared the COVID-19 outbreak a pandemic – US federal authorities a U-turn and said all Americans should presumably wear face masks in public settings, and be aware of asymptomatic carriers.

So how contagious is someone who has contracted COVID-19 – still showing no symptoms? This study, published this week in the medical journal JAMA Internal Medicine, provides one theory for the first question. It isolated 303 patients with COVID-19 in a treatment center in South Korea. Of these, 110 (36%) were asymptomatic and 21 (19%) developed symptoms during isolation.

What they found: “Many individuals with SARS-CoV-2 infection remained asymptomatic for a long time, and viral load was similar to that in symptomatic patients,” the scientists concluded. “Therefore, isolation of infected persons should be performed, regardless of symptoms.” The researchers analyzed swabs taken from the group between March 6 and March 26.


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