Why are not all members of a family infected with the new coronavirus at the same time? Link to individual genetic makeup



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The way the coronavirus is transmitted has not been precisely established, and this situation is seen in the reports of the authorities that show thousands of new infections every day.

It seems that SARS-CoV-2 can be taken anyway and from anywhere and can be contaminated even when you go out on the balcony. But there are people much more fortunate, who stay at home with patients, but do not get infected. Experts say that the reaction to the virus depends on everyone’s DNA.

Doctors say that these cases are not unique even in the conditions in which, in the family, the isolation cannot be perfect because they have common spaces and there is a risk of infection.

“There are two situations that can be discussed. The first is when the immunity of other family members is very good and they manage to destroy the coronavirus when it enters the body.

There are studies carried out at this time that state that in some people macrophages (a subcategory of blood cells, with an important role in the immune system) have the ability to trap the SARS-CoV-2 virus that reaches the lungs and neutralize it . . But we don’t know what the type of person is and what genetic makeup they have that allows this type of extremely efficient response ”, explained Dr. Beatrice Mahler, manager of the Marius Nasta Hospital in the Capital, for Ziare.com.

Longer incubation period

The doctor also said that it is about another situation. “We had a case where the whole family got sick and one of their members didn’t get sick. But he tested positive, but asymptomatic, much later, after 14 days. He was accidentally tested for contact during the period. the one who tested contacts of positive people, but from another source; had contact with another person a week after taking the test, and this time it came out positive; people relax when they see that they have had cases in the family and not they were embellished.

It can be a long-term incubation, because for some patients, the incubation period, precisely because the autoimmune response is good, can be longer, not 14 days, not 5-6 days. The average is 5-6 days, but we have people who are positive 24 hours after contact and we have cases of people who are positive after 21 days.

I think people who have very good immunity can be positive late. That is why, given community transmission, we must wear a mask at all times, to protect ourselves, until we have a vaccine to help us.

And it could also be the situation where, people who have very good immunity, if the concentration at the level of the nasopharynx, the place where the sample is collected is very low, the test may be negative. But that does not mean that the infection does not exist in the body, “said Dr. Beatrice Mahler.


The doctor also specified that the incubation period also depends on the amount of virus the patient is exposed to.

“When I had the first cases of contagion from the medical personnel, with that colleague who did not follow the procedure and was exposed to a large amount of virus in the room, her symptoms began within 24 hours. She got very positive because “We had to ventilate the rooms very well and keep in mind that all the measures we take to prevent infections are only effective if taken together,” said Beatrice Mahler.

“In the future, genetic diagnosis will be important”

“As it has been shown that there are families that in the genetic algorithm develop severe forms of deterioration in the SARS-CoV-2 infection, it is likely that there are families that develop asymptomatic or mildly symptomatic forms and do not deteriorate rapidly.

I am inclined to believe that genetic diagnosis, in the future, will be part of the prophylactic indication table, what types of vaccines we should do, what types of treatments we should do each one to prevent genetic diseases, diseases that may be found in our genetic makeup ”, explained the director of the Marius Nasta Institute.

The latest report from the authorities shows that 6,171 new cases and 204 deaths were registered in just 24 hours. 1,255 patients in serious condition are hospitalized in ATI. In total, from the beginning of the pandemic to the present, 565,758 people have been confirmed infected with SARS-VOC-2 in our country.

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