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Physician and researcher Adrian Streinu Cercel disagreed with the words of Ionuț Nistor, principal nephrologist at Parhon Hospital in Iași.
The manager of the Matei Balş Institute contradicted his colleague and told him that Hydroxychloroquine and Kaletra have so far proven their effectiveness in the fight against Covid-19.
The conflicting discussion began after Nistor indicated that these drugs should be removed from therapy for those with Covid-19.
The rather heated dialogue took place on Monday night, during the program Archivo del politico, broadcast on B1 TV.
Streinu-Cercel summoned his confreres
Thus, the new PSD candidate in the parliamentary elections rejected the observations that hydroxychloroquine was inefficient and increased the death rate.
The manager of the Matei Balş Institute stated that the effectiveness of the drug depends a lot on the stage at which it is administered.
He also cautioned that both hydroxychloroquine and other medications should be kept in the treatment regimen.
The explanation is related to a black scenario in which medical personnel in Romania will no longer have anything to treat patients at some point.
Ionuț Nistor knows his
In turn, Ionuț Nistor is convinced that hydroxychloroquine and plaquenil should be eliminated from the therapy of people diagnosed with Covid-19.
„Adrian Streinu-Cercel: We follow the data from the specialized literature. The problem is that we had a series of medications that were taken from the beginning, in February, and we had a series of data.
Right now, after so many months, we are talking about other potentially much more active drugs, such as monoclonal antibodies.
The portfolio of these drugs is very interesting. No drug, at this time, is one that saves human life when seeing with the eyes, they are all therapeutic schemes that change according to the type of patient, because there are no diseases, but there are patients.
Ionuț Nistor: We agree that at the beginning of the pandemic it was necessary to test any drug that studies had shown potentially beneficial in the fight against the pandemic, but after this initial period, we see that we can give some of them. aside and go ahead with other medications.
Unfortunately, we have to put aside this therapy with the drug called Kaletra commercially, just as we have to put aside the therapy with Hydroxychloroquine or Plaquenil for patients with COVID-19 ”, was the beginning of the debate between the two.
Invitation to moderation and temperance
In response, Adrian Streinu-Cercel advised Ionuţ Nistor to filter statements about this treatment scheme:
“Adrian Streinu-Cercel: I would say that we should be moderate regarding these data. It depends on when you use hydroxychloroquine, if you use it in the severe patient, it is worthless.
Ionuț Nistor: Studies say that these initial data, which suggested antiviral potential, from both Plaquenil and Kaletra, are not clinically confirmed.
Unfortunately, even if a sufficient concentration of antiviral activity was reached, there were no benefits for Covid-19 patients, both for patients in the early stages and for those in the medium and severe stages, and mortality did not decrease. “.
Who is right, who is confusing?
After the dialogue, Streinu-Cercel taunted his discussion partner, suggesting that he did not master the information about the effectiveness of the treatment:
Adrian Streinu-Cercel: Here we make little confusion and give everything about mortality. It’s not just about mortality.
This problem also includes the quality of life during the patient’s illness.
If it improves and shortens the hospital stay by two days, it is an important element for a patient who is locked in a room where he has no access to anything.
We must be careful because we will be in a situation where we may not have anything to give to these patients.
It is very true that lopinavir comes with an unpleasant side effect, namely diarrhea.
I recommend that these drugs remain in the wallet because then we may have to use them again.
At the moment they are used, they are not used in the doses indicated in the package leaflet.
Ionuț Nistor: These drugs are approved by ministerial order, then they are mandatory for the treatment of patients with Covid-19.
Adrian Streinu-Cercel: No, no, careful, they are not mandatory.
Ionuț Nistor: They are not required, but most patients receive them. At this time, there are no randomized studies demonstrating efficacy on mortality or other benefits for both Kaletra and Plaquenil. If it has no benefit and there are more side effects, why keep giving them? “
The conclusion? Are they good or not?
„Adrian Streinu-Cercel: Because it is written in any leaflet that is used in the context in which the treating physician analyzes and considers that the beneficial effects for the patient outweigh the side effects. This is a well-known principle in medical practice.
Ionuț Nistor: I recommend stopping those who can do harm. The only one proven so far is dexamethasone and corticosteroids ”, they also said.
Streinu-Cercel had the final answer, stating that issues related to drugs administered to Covid-19 patients should not be debated in the press.
He justified his opinion by stating that there may be situations in which some patients reject certain medications based on the advice heard by some or other specialists.
source: b1.ro
