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Hypertrophic cardiomyopathy (MCH), which is a symptom that blood does not enter the heart as the heart muscle enlarges / Photo = Harvard Medical School provides Sedman Lab |
| Hydroxychloroquine products sold at Razil Pharmacy |
Studies have shown that hydroxychloroquine, developed as a treatment for malaria, is administered to patients with new coronavirus infections (corona19), increasing the risk of arrhythmia with irregular heartbeats.
In particular, scientists caution that the use of hydroxychloroquine with the antibiotic azithromycin may cause greater electrical changes that stimulate the heart rate than when hydroxychloroquine alone is used.
United States President Donald Trump began to say that hydroxychloroquine and chloroquine could have a good effect on Corona19 since mid-March.
On the 21st of the same month (local time), “Hydroxychloroquine and azithromycin may be the biggest game changer (game changer).”
The use of these antimalarial drugs in the United States was reported to be increasing rapidly, and pharmacy sales of chloroquine increased 114-fold.
The institution that conducted the study was the Beth Israel Deacones Medical Center (BIDMC) in Boston, a clinical training hospital at Harvard Medical School in the United States.
The article was published in the journal “ JAMA Cardiology, ” published by the American Medical Association on Day 3.
Dr. Nicholas J. Mercury, Ph.D. in pharmacology, co-author of the article, said: “In patients with heart disease, the corona effect19 is not uniform. Noted.
The rhythm of the heartbeat is determined by the stimulation of electrical signals formed in the area called the sinoatrial node.
Arrhythmia is an irregular heartbeat caused by a change in this electrical signal. If you continue, your risk of heart attack or stroke may increase.
Hydroxychloroquine and azithromycin cause electrical disturbances in the heart on both sides, called “QTc prolongation.”
The maximum interval for an electrocardiogram (ECG) test is extended even if the cycle through which electricity flows to the heart muscle is only a few thousandths of a second.
The researchers examined 90 adult Corona19 patients who entered the BIDMC from March 1 to April 7 and were treated with hydroxychloroquine for at least one day. At the time of hospitalization, most of these patients had hypertension, and more than 30% of people with diabetes.
Seven patients, 19% of the patients who received only hydroxychloroquine, had QT of more than 500 ms (milliseconds, thousandths of a second), and three had “more than 60 ms and less than 500 ms”.
Among 53 patients who received azithromycin together, 21% had more than 500 ms and 13% had “more than 60 ms and less than 500 ms”.
In particular, one of the patients using both drugs had a fatal cardiopulmonary hyperactivity disorder called “polymorphic ventricular tachycardia” (torsades de pointes).
So far, none of the Corona 19 studies have gone through a ‘peer review,’ the researchers say.
“Judging from our current knowledge, it is appropriate to limit hydroxychloroquine treatment to clinical trials in clinical trials,” said Howard S. Gold, assistant professor at Harvard Medical School, lead author of the article.
Meanwhile, authorities in the northern Brazilian Amazon city suspended clinical trials in which 81 patients in Corona19 were given hydroxychloroquine in the middle of last month after side effects such as heartbeat abnormalities continued.
[MBN 온라인뉴스팀]