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University hospitals of the Tübingen Ophthalmological Research Institute and the team of pharmacology and ophthalmology at Ludwig Maximilian University in Munich recently replaced the faulty gene by injecting a normal ‘CNGA3’ gene into the retina. He managed to improve the ability to distinguish colors.
Color blindness refers to a condition in which color cannot be distinguished normally due to vision problems caused by cone cell problems. It is divided into total color blindness, partial color blindness and color weakness. There are three types of cone cells: red, green, and blue, which are stimulated to mix colors and recognize all colors based on the mix ratio. If there is no cone cell of the color, it is a colorblind of the corresponding color, but there is a cone cell.
“Full color blindness” is a symptom in which all objects appear gray because they cannot distinguish green, blue, and red. The “CNGA3” gene defect, which is found in a conical cell and performs the function of distinguishing color by detecting light, is 3 minutes cause Occupies 1 of.
The team placed the CNGA3 gene into the adenovirus, which is harmless to the human body, and then injected the virus into the retinas of nine patients with complete color blindness between the ages of 24 and 59, confirming recovery from color discrimination.
“There were no side effects on the retina and other parts of the body after the injection,” said Dominic Fischer, professor of ophthalmology at the University of Tübingen, Germany, responsible for the clinical trials of the study. “The contrast and color vision capabilities of both showed significant improvement.”
The results of this study were published in the recent issue of the American Association for Medical Sciences (JAMA Ophthalmology).
Adenovirus
Adenovirus was first discovered in 1953 in adenoid tissue. It was named adenovirus after the organization. Human adenovirus is a virus that primarily causes respiratory illness in children, but also causes epidemic respiratory illness in dense environments, even in adults.
Since adenovirus is easy to grow in cells and easy to manipulate, more information on gene expression, regulation, and proliferation of viruses and cells is possible as research continues. Recently, since adenovirus is used as a vector that delivers the gene we want, many studies have been done to use it as a gene therapy product.
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