[전국]”Rapid multiplication of virus in lungs in 6 hours” … Corona 19 infection process identified

[앵커]

There are signs of a second pandemic, with the cumulative crown19 confirmed worldwide to exceed 43 million.

For the first time, joint researchers at home and abroad, such as KAIST, cultivated corona 19 virus in the lungs of humans raised in a laboratory to destroy cells.

It is expected to be of great help in developing effective treatments.

This is reporter Lee Jung-woo.

[기자]

Corona 19 virus is difficult to infect mouse models and, in particular, there is no lung cell model available in the laboratory, which limits infection studies.

In the midst of this, joint national and international researchers, such as KAIST and the University of Cambridge in England, developed the 3D mini organ technology that makes human alveoli, the so-called cells of the lungs, in a laboratory.

This is the first time that the Corona 19 virus has destroyed human lung cells.

[김태우 / KAIST 의과학대학원 석박사통합과정(공동 제1저자) : 사람 폐포 세포를 3D 배양기술로 개발을 했고 그걸 이용해서 코로나 바이러스가 어떻게 폐포 세포를 감염시키는지를 규명한 연구입니다.]

The researchers found the conditions for a stable 3D culture of human lung tissue and created a 3D human alveolar model that can be grown continuously.

As a result of the experiment, when the alveoli were exposed to the Corona 19 virus, rapid viral proliferation occurred within 6 hours and the cell infection ended, but it took around 3 days to activate the innate immune response of lung cells to prevent it.

They also found that from day 3 of infection, some of the cells rapidly lose their intrinsic function, along with the fact that one viral particle is enough to infect a single cell.

The researchers explained that the three-dimensional human alveolar model could be applied directly to the development of COVID-19 treatments, as well as to study other respiratory viral diseases.

[주영석 / KAIST 의과학대학원 교수 : 약물 스크리닝이나 질병 기전을 규명하는 데 사람의 폐포를 이용하고 직접적 연구를 하게 됨으로써 좀 더 효율적이고 빠른 연구를 수행할 수 있을 것으로 생각됩니다.]

The results of this research, which were joined by the University of Cambridge, the National Institute of Infectious Diseases, the Basic Sciences Research Institute (IBS), the Seoul National University School of Medicine, and startups from the KAIST faculty, were published in the online edition of ‘Cell Stem Cell’, a world-class academic journal in the field of stem cells.

YTN Lee Jung Woo[[email protected]]is.

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