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Korean researchers have developed a proprietary aging reversal technology that can rejuvenate old cells into young cells.
The Korea Advanced Institute of Science and Technology (KAIST) announced on the 26th that the research team of Professor Gwang-Hyun Cho in the Department of Biological and Brain Engineering has developed an early source technology to reverse aging to return dermal fibroblasts. aged humans to normal young cells.
The research team developed a program that implements a computer-implemented cellular aging signaling network of human dermal fibroblasts and simulated them to find the key factors necessary to return old cells to young cells. In addition, by controlling this key factor, it has established a reverse aging technology that increases the synthesis of reduced collagen in aging skin tissues and restores the regenerative ability to show the characteristics of young skin tissues. The research team’s thesis was published in the International Journal (PNAS).
Currently, the method that has been studied mainly as a rejuvenation strategy is to de-differentiate already differentiated cells by temporarily expressing the ‘OSKM transcription factor’ by Professor Shinya Yamanaka from Kyoto University in Japan and California State University in the United States, Nobel Prize in Physiology or Medicine 2012. In this way, senescent cells return to a younger state. However, this technology has the limitation that cancer-causing side effects such as tumor formation occur.
Professor Gwang-Hyun Cho’s research team is a key regulator that returns aged human dermal fibroblasts back to young cells. We find the upper regulatory factor ‘PDK1’ (PDK1) that simultaneously controls F-KB ‘(NF-kB).
The research team demonstrated that senescent cells can be rejuvenated by inhibiting PDK1 through experiments with molecular cells and aging artificial skin models. When PDK1 was suppressed in aged human dermal fibroblasts, markers of cellular aging disappeared and functions as normal cells that respond appropriately to the surrounding environment were confirmed.
Based on the results of this research, the Amorepacific Institute of Technology, which has collaborated with the research team, is developing cosmetics that improve aging skin wrinkles by extracting the inhibitory ingredient PDK1 from camellia extract, KAIST said.
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