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On the 20th of last month, the research team of Professor Remy Charel of the University of Aix-Marseille, France, recently observed the Corona19 virus on the thesis pre-launch platform (bioRxiv) after heating from 60 ° C to 140 ° C “It still replicated the virus even when heated for an hour.”
In particular, at a time when corona gravity19 is gradually showing, as the coronavirus replicates even at temperatures above 60 degrees Celsius, Korean scientists are discovering the world’s first substance that reduces the replication of the coronavirus19, giving a new hope to the world.
Kim Hong-ryul, CEO of HaimBio Co., Ltd., said: “Based on inorganic polyphosphate research, we have uncovered an important clue to developing the corona19 virus treatment without side effects for the first time in the world ” Announced Meet Hong-Ryeol Kim, CEO of Heim Bio and hear the detailed story.
-Corona 19 is the first substance in the world that degrades replication?
▶ Yes That’s correct For the first time in the world, a candidate for corona19 treatment without side effects was discovered in collaboration with a research team from Yonsei University School of Medicine. The discovery of inhibition of the host replication function of the coronavirus infection virus (COVID-19) using phosphorous polymers was the result of a joint study with the research team of the Yonsei University School of Medicine .
-What is phosphorous polymer?
▶ Inorganic Polyphosphate is a polymer in which at least 3 to more than 1,000 phosphates (PO43-) are connected to each other to form a linear material, found in almost all living organisms such as bacteria, fungi, plants, and mammals. Is.
In particular, phosphorus is an important precursor that is the origin of life: it is an energy metabolite of all cells, a source of ATP supply, an energy source, storage of phosphate groups, binding with metal ions, regulators for stress and survival, and occurrence regulators. It is an inorganic compound that has a function and is a substance that can develop various new drugs.
-How is the safety of the polymer?
▶ It has been approved by the FDA as a food and drug additive and has been shown to be safe.
-What motivated you to develop the Corona 19 treatment with In-Polymer?
▶ In 1997, the German research team began focusing on the results of a study in which various long-chain phosphorous polymers have the role of inhibiting infection with other viruses, the AIDS VIRUS (HIV-H1).
Research on the polymer began when I completed my doctorate at Calton University in Canada by replicating plasmid DNA from a heterogeneous bacterium, and in the postdoctoral course in the laboratory of Nobel Prize-winning Dr. Author Kornberg.
It is a substance that has been studied with interest by university professors and companies for 30 years.
This experiment was created by recalling data from the 1995 laboratory meeting in the biochemistry class at the Stanford School of Medicine while studying the relationship between phosphorus polymers and cancer, in addition to research teams from the School of Medicine. Yonsei University Medicine.
Then, according to a study published at the University of Mainz, Germany, “Inpolymer has antiviral properties for the AIDS virus” mentioned in the 1997 article, it was obtained by conducting an experiment on a confirmatory sample with the help of teams from the Yonsei University School of Medicine. The result
-Is it said that the actual experiment was carried out with a sample of 19 crowns in Korea?
▶ Recently, a sample of a coronavirus infectious disease (COVID-19) was provided and analyzed. Yonsei University experimented with how coronavirus phosphate polymers of various chain lengths act on the coronavirus at different concentrations. As a result, it was the first time that coronavirus replication in host cells was inhibited at significant levels at different chain lengths and at different concentrations.
Did you announce that Corona 19 is conducting the same experiment in Italy, one of the most serious countries?
▶ Research is carried out quickly through international cooperation.
As a result of a sample test performed by a national confirmer, it was discovered that the replication capacity of the Corona 19 virus was inhibited and Dr. Massimo Zollo of CEINGE, a biotechnology research center located in Naples, Italy, was immediately contacted. Infection with the coronavirus in Italy (COVID-19) It is a comparative analysis of the same phosphorous polymer sample used in experiments carried out in Korea using oropharyngeal cells as the final Italian sample.
-When did you start researching polymers?
▶ It started in 1993 while attending Stanford Medical School in the United States. Under the direction of Dr. Arthur Kornberg, Nobel Prize in Physiology for Medicine, he began studying polymers during his postdoctoral training.
-Which was Kim’s oldest?
▶ I am the first polymer research expert in Korea. He is also the main character who created the Kyung Hee University School of Oriental Medicine. Furthermore, while studying molecular genetics at the University of Calton, Canada, he studied the replication capacity of plasmid DNA in heterogeneous bacteria and in soil bacteria that gave fatal results to pulmonary fibroblastoma by inducing asthma, especially in the field of DNA replication. and polymerization indoors while studying at Stanford School of Medicine in the United States. We have discovered a phenomenon related to the heart attack related to the enzyme that produces this substance.
-How is the study of phosphorus polymers going in the future?
▶ Based on collaboration with research teams from Yonsei University School of Medicine, we are conducting close core experiments in collaboration with the Italian research group, which is in collaboration with the research team, in both countries. simultaneously with samples from patients with a royal crown. In Korea, we will also receive joint research and advice from academics with long experience in the field of virus replication, and Professor Seong Baek-rin from the Department of Biotechnology, Yonsei University, the country’s leading academic in the field of virus.
-Has a patent been filed in relation to Corona 19? Future plans?
▶ Completed a patent application for ‘Pharmaceutical composition of Corona virus infection for prevention and treatment’. The patent was 100% agreed with the co-inventors in the transfer key to Heim Bio. It will soon be announced through an international academic journal.
Currently, the world is struggling with the lack of treatments due to virus attacks, so we plan to jointly experiment in Korea first, and we will also start researching with famous foreign universities to contribute to the completion of treatments.
We are also developing anticancer drugs for aerosol products that use cancer-free polymers and cancer of the refractory molecular subtype, and we plan to continue research from various perspectives that require the development of coronavirus treatments and vaccines.
-Finally, is the ongoing clinical trial of cancer treatment going smoothly?
▶ Clinical trials are currently underway at Severance Hospital. Starvanip (NYH817100), a cancer drug that is a candidate for the next-generation cancer drug that starves and kills cancer cells, is progressing smoothly in phase I clinical trials for several cancer patients who fail standard treatment in the oncology department of Severance Hospital, Yonsei University.
