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Concerns about the rare inflammatory disease affecting minors and a common feature of Cavassaki disease are increasing worldwide, according to a new study from Italy linking the mysterious disease for the first time. with the crown
Specifically, scientists in Italy reported ten cases of children with Covid-19 disease, who have symptoms similar to the rare inflammatory Kavasaki disease. The average age of the children (seven boys and three girls) was seven and a half years, while none died.
The announcement comes after similar findings from doctors in Britain (where the first cases and the first death of a child were reported) in New York (where nearly 100 children infected with the SARS-CoV-2 coronavirus showed symptoms similar to those of Kavasaki disease). and three of them died), in France, Spain and Switzerland.
Italian doctors, led by pediatrician Lucio Verdoni in a Bergamo hospital, made the relevant publication in the medical journal “The Lancet”.
“We noted an increase in the number of children admitted to our hospital with an inflammatory disorder similar to Kavasaki disease at approximately the same time as the coronavirus outbreak in our area. Although this complication remains very rare, our study provides more evidence of how the virus can affect children, “said Dr. Verdoni.
“I have no doubt that the inflammatory disease in these patients is caused by the coronavirus,” said Dr. Lorenzo D’Antiga, a pediatrician at the hospital.
The symptoms of Kawasaki, the cause of which has always been unknown, include abdominal pain, high fever, nausea, vomiting, severe skin rashes, and biomarkers of high blood pressure. They are treated with high doses of aspirin, anti-inflammatories, and immunosuppressants. But if treatment is delayed, the child, due to inflammation in the blood vessels, may have heart problems.
In Lombardy, Italy, only 19 children have been diagnosed with Kavasaki disease in the past five years before the Covid-19 outbreak, and this year in February-April there were ten cases similar to this disease. According to the study, over the past two months, pediatric cases like Kavasaki show a 30-fold increase compared to the time before the pandemic (so only one Kavasaki case appeared on average every three months).
Children admitted to Bergamo Hospital with Cavassaki-like symptoms in the midst of a pandemic are at least three years older than children diagnosed with Cavasaki before the pandemic (they were generally babies of approximately three years). They also have more severe symptoms than in the past, with more than half of heart complications, compared to just two in 19 before coronary heart disease. Another half has signs of toxic shock syndrome (which can lead to organ failure), a complication that had not occurred at all in children with Kavasaki prior to the pandemic.
“In our experience, only a very small percentage of children infected with the SARS-CoV-2 virus show symptoms of Kavasaki disease,” said Dr. Analyza Gervasoni, a pediatrician at the same hospital. It is estimated that, at most, one in 1,000 children exposed to the coronavirus will develop Kasavaki-type symptoms, and a smaller percentage of them will have to be admitted to an intensive care unit (ICU) due to serious complications.
Other viruses have been linked to Kavasaki disease in the past, such as retroviruses, Epstein-Barr virus, and chlamydia. To date, however, no virus has been confirmed to be the cause of this disorder. In any case, more research will be needed to convince doctors that the new crown is actually “shooting” Kavasaki. It should be noted that Kavasaki disease is considered one of the most difficult diseases to diagnose in pediatrics.
On Monday, New York health officials released a statement to experts urging them to report any related incidents. Some of its symptoms are similar to those of Kavasaki disease, such as fever, abdominal pain, and skin rashes, but experts note that there are clear differences in how the two syndromes affect the heart. Although toxic shock is a very rare Kavasaki complication, the children who fell ill with “pediatric polycystic ovary syndrome” were immediately shocked, greatly hypotensive, and unable to oxygenate and nourish their vital organs. Kavasaki causes aneurysms if no treatment is given, but the new syndrome causes inflammation of the coronary arteries and all the blood vessels.
with information from ΑΠΕ-ΜΠΕ, NYT
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