Triple combination of antiviral drugs holds promise for treating COVID-19



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A two-week course of antiviral therapy combining the power of three drugs has shown promise in treating hospitalized patients with mild to moderate COVID-19 in a carefully conducted Phase 2 clinical trial.

The results of the trial, published in The Lancet, involved 127 adults from six public hospitals in Hong Kong.

The combination of drugs tested in the trial included interferon beta-1b, which was developed to treat multiple sclerosis (MS) and lopinavir-ritonavir, which is normally used to treat HIV and ribavirin, an oral drug for the HIV virus. hepatitis C.

Findings from the phase two trial provided evidence that early treatment with triple antiviral therapy in conjunction with standard care is safe and shortens the duration of virus clearance (when the virus is detectable and potentially transmissible) compared to lopinavir-ritonavir alone: ​​average of seven days versus 12 days —In patients with mild to moderate COVID-19.

“Our trial demonstrates that early treatment of mild to moderate COVID-19 with a triple combination of antiviral drugs can rapidly suppress the amount of virus in a patient’s body, alleviate symptoms and reduce the risk to healthcare workers by reduce the duration and amount of viral excretion, “said Professor Kwok-Yung Yuen of the University of Hong Kong who led the research.

No new cases in Hong Kong as restrictions are eased

Hong Kong did not record any new cases of COVID-19 on Saturday, a day after the city eased the restrictions. Saturday was also the 20th consecutive day without local infections. Health experts previously suggested that Hong Kong could be considered free of local transmission if there were no such cases after 28 days.

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