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Susanna C. Larsson
Increased alcohol consumption predicted by genetics was associated with an increased risk of peripheral artery disease and stroke, according to a study published in Circulation: genomic and precision medicine.
According to the study, this causal relationship was not seen in heart failure, aortic valve stenosis, or venous thromboembolism.
“Our findings show that alcohol consumption increases blood pressure and the risk of stroke, peripheral arterial disease, and possibly other cardiovascular diseases.” Susanna C. Larsson, PhD, Senior researchers and associate professor of cardiovascular and nutritional epidemiology at the Karolinska Institute in Stockholm, Sweden, told Healio. “Given that alcohol is a risk factor for high blood pressure, stroke and peripheral arterial disease, alcohol consumption should be considered in moderation in any case.”
The researchers used 94 single nucleotide polymorphisms to assess the possible relationship between alcohol consumption and CVD outcomes in the UK Biobank participants. The primary outcomes of CVD in this study included atrial fibrillation, CAD, stroke, VTE, IC, PAD, abdominal aortic aneurysm, and aortic valve stenosis.
Genetic data predicted alcohol consumption was associated with an increased risk of stroke (OR for 1 standard deviation [SD] increase in logarithmically transformed alcoholic beverages per week = 1.27; 95% CI, 1.12-1.45) and PAD (OR for 1 increase SD of logarithmically transformed alcoholic beverages per week = 3.05; 95% CI, 1.92-4.85).
In the inverse variance weighted analysis, some evidence of a positive association of genetically predicted alcohol consumption and AF was observed (OR = 1.17; 95% CI, 1-1.37), CAD (OR = 1.16; CI of 95%, 1- 1.36) and AAA (OR = 2.6; 95% CI, 1.15-5.89). Associations were somewhat attenuated after adjusting for smoking onset in a multivariable Mendelian randomization analysis.
There was no association between genetically predicted alcohol consumption and VTE (OR = 1.04; 95% CI, 0.77-1.39), CI (OR = 1, 95% CI, 0.68-1.47) and aortic valve stenosis (OR = 1.03). ; 95% CI, 0.56-1.9).
“There is a need for more, even larger, studies evaluating the causal relationship between alcohol use and other cardiovascular diseases in addition to stroke,” Larsson said in an interview. – by Darlene Dobkowski
For more information:
Susanna C. Larsson, PhD, He can be contacted at [email protected].
Divulges: The authors do not report relevant financial disclosures.
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