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The results of the study, which was carried out in the laboratory of the Faculty of Biology and the Department of Biochemistry and Molecular Biology of the university since last July, were released to the media this Saturday.
Rabiul Hasan Bhuiyan, associate professor in the Department of Biochemistry and Molecular Biology, a member of the research team, told bdnews24.com that the virus was found in the United States, Europe, Saudi Arabia, Taiwan, India and Australia.
And in the analysis of 30 gene sequences, 126 different mutations have been found in the genetic structure of this coronavirus in different areas of the department. Five of these mutants are more prevalent in Chittagong, said HM Abdullah Al Masood, assistant professor in the Department of Microbiology, another member of the research team.
Associate Professor of Plant Sciences. Mohammad Omar Farooq Russell said they started this study to find out from which areas the coronavirus came to Chittagong and what kind of mutations or genetic changes have occurred after coming here.
“The main objective of the study was to give an overview of the Covid-19 situation in the Chittagong Division. For that purpose, samples of covid-positive patients were collected from each upazila of 11 districts of the department ”.
Of the 300 samples initially collected, 48 samples were selected for genome sequencing after some verification steps. Of these, more than 99 percent of the genome sequencing of 33 samples has been discovered. Of these, two or three samples were from each district.
Omar Farooq Russell said that after analyzing all the data from 30 samples, the 12-sample genetic format was submitted to GISAID.
Associate Professor Rabiul said that in reviewing district data, they found that the United States, Germany, Italy, the Czech Republic, Saudi Arabia and Taiwan, along with district samples from Chittagong; United States, Germany, Australia, India, and Japan with samples from Noakhali, Laxmipur, and Feni districts; United States, Germany, Czech Republic, India and Japan with samples from the districts of Comilla and Chandpur; United States, Germany, Saudi Arabia and India with the Brahmanbaria sample; Samples from Cox’s Bazar, Rangamati, and Bandarban were found to have “greater similarities” to samples from the United States, Sierra Leone, Germany, Italy, Taiwan, and the Czech Republic, and samples from Australia, Saudi Arabia, and Taiwan in the district of Khagrachari.
Abdullah Al Masood said that the five coronavirus variants that have spread widely in Chittagong are I1300F in ORF1a, D614G in S, P314L in ORF1b, R203K in N, and G204R.
Of these, the D614G mutation of the spike protein (S) makes the coronavirus much more contagious. The researcher said that this mutation was found in 30 samples.
He said the samples they analyzed showed a total of six nucleotide changes in different parts of the gene, but no changes in amino acids.
Omar Farooq Russell said: “In most cases, the world is trying to make peak protein-based vaccines. Five mutations have been found in the spike protein format along with other mutations, which have been found in other countries, but this is the first time it has been identified in Bangladesh.
These are the S155I, N354S, S477N, P681H and V1122L models. P681H is one of the mutations found in new coronavirus variants recently found in the UK, he said.
Another member of the research team, Assistant Professor Imranul Haque from the Department of Microbiology, said: “We hope that our revealed genetics will provide information on the nature, spread, origin, diversity and mutations of viruses in all districts of the Chittagong Division, which is important for the future Covid-19. He will play a role. ”
Among others, student of the Department of Botany of the University. Khandaker Raziur Rahman, Imam Hossain, Arif Hossain and Sajib Rudra, Shanta Pal from the Department of Microbiology and Md. From the Department of Biochemistry and Molecular Biology. Omar Farooq participated in the study.
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