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Regarding genetic testing of newborns, Dr. Hong Jiazheng noted that Next Generation Sequencing Technology (NGS), combined with newborn screening and genetic testing for drug allergies, can detect 208 genes and 200 diseases simultaneously by drawing blood. And anticipate drug reactions in advance, avoid drug allergies, and provide genetic testing for up to 12 major diseases.
Obviously the same medication, some people will not be allergic, but some have rashes after taking the medication. Research indicates that this may be related to genes. According to the Drug Relief Foundation, the gout treatment drug Alopurinol and the epilepsy drug Carbamazepine, which trigger compensation for drug damage, are allergic reactions to these drugs and special genes in the body. Fortunately, as medical research progresses to precision medicine, newborns can accurately identify genes for allergic drug reactions through genetic testing as soon as they are born.
The lethal rate is as high as 50%. Severe drug allergy is related to genetic variation
After taking the medicine, there are rashes, ulcers in the throat or oral mucosa, sore throat, swollen lips and fever. The drug is suspected to be allergic. Most people are allergic to the drugs and will get better after stopping the drug. Some people are not so lucky. His eyes are burning, swallowing discomfort and even blisters. Only about 10% of patients with Stephen Johnson syndrome (SJS), which is a serious adverse reaction to the drug, can be fatal. In the case of severe toxic epidermolysis (TEN), large-scale epidermal damage throughout the body, ulceration of the mucosa of the mouth and eyes, the mortality rate is as high as 50%.
Dr. Cai Changlin, a special clinic for pregnant women and children with skin conditions from a known medical group, said that rashes, breaks, pain, redness, swelling, and fever are the six main precursors to drug allergies. Allergic drug reactions can be large or small, skin rashes, itching and ulceration of the skin, serious drug allergy genes, and serious fatalities can cause allergies. A
Taiwanese are at high risk of drug allergy due to genetic testing to ensure the safety of the drugs.
The international scientific journal “Nature Medicine” (Nature Medicine), a genetic study of serious adverse drug reactions: Stephen Johnson syndrome and toxic epidermolysis, found that the genes that cause Stephen Johnson syndrome and toxic epidermolysis, and the genes that carry this gene The proportion of Asian ethnic groups is much higher than that of Caucasians.
Hong Jiazheng, Ph.D., Institute of Genomic and Proteomic Medicine, National Taiwan University, said that compared to two to three out of every million people in Europe and the United States, SJS occurs in Taiwan. Eight out of every million people occur, with an average of every two days. Increase cases. Through the evolution of pharmacogenetics, the association between drug genes and severe drug allergies is gradually established. The United States FDA recommends that Asian patients undergo genetic testing before using certain medications to ensure safety.
The really organized anesthesia storm malignant high fever is unpredictable
Dr. Cai had found a case where her parents were allergic to common narcotics for surgery and did not want the same thing to happen to their baby. Allergic reactions to narcotic drugs can be mild or severe. Malignant hyperthermia caused by the television series “Narcotic Storm” is the most serious condition. Patients with muscle stiffness, spasms, shortness of breath and arrhythmia, etc., if not properly treated, can cause death. Malignant hyperthermia is not only difficult to predict before surgery, but it usually occurs suddenly during the operation, and the symptoms change rapidly, causing people to be caught off guard. A
Although malignant high fever has the antidote Dantrolene, it must be detected early for a chance to save the patient. Because malignant high fever comes primarily from genetic genes, people with a family history must undergo genetic testing to avoid regrets.
▲ Blood samples to collect a small amount of blood
Protecting newborn health A small amount of blood once in a lifetime to detect 200 types of pathogenic genes
Regarding genetic testing of newborns, Dr. Hong Jiazheng noted that Next Generation Sequencing Technology (NGS), combined with newborn screening and genetic testing for drug allergies, can detect 208 genes and 200 diseases simultaneously by drawing blood. And anticipate drug reactions in advance, avoid drug allergies, and provide genetic testing for up to 12 major diseases. This newborn genetic test is different from health screening, it should only be done once in a lifetime, which helps parents protect the health of the newborn wholeheartedly on the way to caring for children.
