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The problems of tracking the survivors of the new crowns are attracting attention, it is not only that these people can have unrecoverable side effects, but there are even cases of recurrence all over the world. Recent studies have indicated that the new coronavirus can hide in the brain in animal experiments, becoming one of the clues of recurrence.
The brain is the central processor of humans and COVID-19 can cause human neurological diseases. Recently, “Virus” published a study that found that mice with neocoronary intranasal infection can cause serious neurological diseases.
The path from the nasal cavity to the brain is more direct than the mouth, and changes in smell and taste are one of the symptoms of COVID-19. Therefore, the researchers inoculated virus cells and PBS into the nasal cavity of the mice. The infected mice began to lose significant weight on day four, accompanied by complications such as lethargy, slow movements, ataxia, and shortness of breath.
Subsequently, the researchers analyzed and found that the amount of virus in the lungs and nasal cavity of the mice reached a peak on the third day and gradually decreased on the fifth and sixth day, while the virus in the brain was only detected in the third day. It reached a high peak on day 5, and the highest virus titer in the brain was approximately 1000 times higher than the highest titer in the lung, indicating that the new corona has a high replication potential in the brain.
On the sixth day after the mouse was infected with the virus, the researchers detected viral antigens related to cells in the brain, including the cortex, cerebellum, and hippocampus. The neurons of the mice contracted and degenerated, perivascular hemorrhage and leukocyte infiltration increased. This finding alone explains why some COVID-19 patients have improved lung function, but can quickly relapse and die.
Since there is no immune response in the brain, it has become a favorite hiding place for viruses. Although patients who have recovered from COVID-19 appear to have escaped the clutches, they can still face health problems including autoimmune diseases, Parkinson’s disease, multiple sclerosis, and general cognitive decline.
參考資料 ： Neuroinvasion and encephalitis after intranasal inoculation of SARS-CoV-2 in K18-hACE2 mice
Text / Image by Lin Yijing / Lin Yijing
Other readings:
COVID-19 / “Lancet” Study of 27,000 Wuhan Infected Families: Infectivity Highest During Incubation Period, Children More Likely to Infect Others
COVID 19 / Don’t you wear a mask for indoor talks? BBC: Risk of infection outweighs cough
COVID-19 / Taiwan’s Oldest Patient With “Toothache” Came to Chang Gung for Medical Treatment
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