Surprising case study for 70 days detects asymptomatic COVID-19 carrier that shed the virus

If we know one thing about SARS-Cavi-2, does it change its effects on people. A lot. As the epidemic progresses, the coronavirus continues to bring new surprises.

A team of researchers and doctors has now reported one case The woman with leukemia did not have symptoms of Covid-19, but even after 70 days of her first positive test, she was exposed to infectious Saras-Cov-2 particles.

This result is much longer than previous reports of hospitalized adults being infected with the SARS-Co-2 virus 20 days after their diagnosis of SOS-Co-2 virus, plus other accounts of people carrying genetic material from the virus for the first 63 to 63 days after their symptoms. . Appeared.

The new report should warn doctors and public health experts alike that people with asymptomatic and weakened immune systems, such as cancer patients, can actually get rid of the good-covy-2 virus for a long time. In this case, even months.

“Although it is difficult to perform extrapolation from a single patient, our data suggest that long-term shedding of an infectious virus may be a concern in certain immune patients,” the research team wrote in their paper describing the case.

U.S. An estimated one million people in India have a condition that compromises or weakens their immune system, making them susceptible to infection. Here are some examples of cancer patients receiving chemotherapy and transplants who take immunosuppressive drugs.

U.S. Vincent Munster, a virologist and co-author of the National Institute, said: “As the virus continues to spread, more people with a higher range of immunosuppressive disorders become infected, and it is important to understand how SARS-Cavi-2 behaves in this population. Is, “U.S. Said Vincent Munster, a virologist and co-author of the National Institute. Allergies and infectious diseases.

Virologists such as Mસ્ટરnster monitored the epidemic for the prolonged viral nature of SARS-CoV-2. It is well established that immunocompromised people can carry the common seasonal coronavirus for weeks after infection.

In Middle East Respiratory Syndrome (MERS) studies, similarly immunocompromised people are hiding the virus that causes the disease for up to a month after infection.

But the extent of the asymptomatic COVID-19 case is still unclear. The danger is that these carriers of the virus could easily spend days unaware of their ability to spread the virus.

In this case, doctors detected, isolated and tracked a woman’s SARS-Cavi-2 infection using diagnostic PCR tests and throat swabs. A decade ago, a 71-year-old woman was diagnosed with chronic lymphocytic leukemia (CCL), a white blood cell cancer that mostly affects older adults and progresses slowly.

He tested positive for the first SARS-Co-2 on March 2, 2020, after being hospitalized for severe cancer-related anemia. She then tested positive for Covid-19 another 13 times and has yet to show any symptoms of the disease.

Twice she obtained plasma from people who had recovered from Covid-19, and finally cleared the virus from her system in mid-June.

Doctors aren’t sure if she got the coronavirus, but it was probably in a rehabilitation facility where there was a large outbreak of Covid-19 in February, where the woman had lived a few days earlier.

From the bottom of her throat during her 15-week infection, the researchers showed that the woman had been carrying infected stork-co-2 particles for 70 days. She also discovered some of her genetic material 105 days after the first positive test.

We should be careful here to see the difference between infectious viral particles and the results of diagnostic tests, which are based on viral RNA. Finds pieces of no. Importantly, the researchers in this study actually isolated SARS-CoV-2 from some swab samples – including day 70 – to test whether the collected virus could replicate in lab-grown cells, which it was.

“This suggests that, most likely, the infectious virus transmitted by the patient will be able to establish a productive infection upon exposure to the infection,” the researchers wrote.

SARS-Cavi-2 in lab-grown cellsSARS-CoV-2 particles obtained from a woman’s throat and cultured in lab-grown cells. (NIAID-RML)

In addition, once doctors were warned about a woman’s case, they quickly accepted it as an opportunity to study how stork-cov-2 could develop during such a long infection.

The researchers sequenced the genetic material of the virus from different samples to see how this particular SARS-Co-2 virus circulated in a woman’s body. At specific times various viral variants became more dominant, but turnover was high and no one stopped.

Further experiments with isolated viruses in lab-grown cells also showed that these genetic changes did not affect the rapid response of the virus.

While this is some valuable insight, more research is needed.

“Prolonged shedding of persistent viruses and infections SARS-CoV-2 occurs more frequently, as understanding the mechanism of virus survival and ultimately clearance will be necessary to prevent transmission of SARS-CoV-2,” the study authors wrote. Their paper.

And yes, this is the only case study, so we can’t make any generalizations about persistent viral shedding in people with other immune conditions, or how effective convulsant plasma is as a treatment for COVID-19, study authors warn.

However, according to the medical research team, “Stork-Cove-2 is the longest-running case of active infection with any therapeutic disease.” They believe the woman has been infected for so long because her tampering immune system has never allowed her to react.

“We’ve seen similar cases with influenza and Middle Eastern respiratory syndrome, which are also caused by coronavirus.” “We expect to see more reports coming out like ours in the future.”

With each, we will definitely learn more about this virus, how long it lasts, and what needs to be done to take care of the most vulnerable people in our communities.

The study was published in the journal Cell.