Probiotics can help manage childhood obesity, the study finds


In combination with a calorie-controlled diet, the probiotic strain Bifidobacterium can help reduce the weight of children and adolescents with obesity, according to a small study released Monday at E-ECE 2020, the 22nd European Congress of Endocrinology.
Our intestinal microbiota is a dynamic population of more than 100 trillion microorganisms in our gastrointestinal tract, and is responsible for maintaining immune function, normal metabolism, and protection against pathogens. Diet is considered to be the main driver of intestinal microbiota, and imbalances in microbiota are associated with diseases and infections.

Just as microorganisms are naturally present in our bodies, some of the bacteria in these probiotics can help in digestion, in the formation of vitamins, and in the destruction of disease-causing cells.

Bifidobacteria are one of the most common bacteria used in probiotics because they live naturally in our stomachs and intestines and protect against pathogens, regulate our immune system, and break down carbohydrates and fiber to provide nutrients. The stress Also produces short chain-fatty-acids, which also play an important role in controlling intestinal health, appetite and weight.

Previous research has used combinations of probiotic strains to evaluate the effect on obesity management, so the authors of the present study tried to find out what happened when bifidobacteria were administered alone.

Probiotics for weight management

The authors studied 100 children and adolescents between the ages of 6 and 18 with obesity and insulin resistance – a condition in which muscle, fat and liver cells do not respond well to insulin and cannot easily absorb blood sugar, resulting in the formation of pancreatic glucose. More insulin to help get in. Decreased absorption produces glucose in the blood over time, potentially setting the stage for the onset of type 2 diabetes.
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“All the children were on a Mediterranean-style diet with a calorie limit according to their needs,” said Dr. Flavia Prodam, associate professor of clinical nutrition at the Department of Health Sciences at the University of Piemontriental in Italy. Then children Got either a probiotic or a placebo for eight weeks.

Both groups eventually experienced a decrease in their body mass index, waist circumference, blood pressure, insulin resistance, and concentration of E. coli bacteria. Participants who took probiotics, however, showed a decrease in weight loss, insulin sensitivity, and E. coli concentration.

The effects of the probiotics continued for a few weeks after the children stopped taking them, said Dr. Christopher Moore, pediatric gastroenterologist and director of pediatric gastroenterology and nutrition fellowship at Boston’s Messin General Hospital for Children. , Who was not involved in the study.

“Several studies have shown that when you stop taking probiotics, they disappear in the gut and have no lasting effects,” added Moore, who is also an assistant professor of pediatrics at Harvard Medical School.

Supports your baby’s gut health

Parents interested in taking care of their child’s intestinal microbiota for weight management or overall health can turn their attention to whole food sources. Many fermented foods and cultured dairy products – such as yogurt, kefir, goat’s milk, aged cheese, kimchi, miso and sauerkraut – contain live probiotics. Packaged foods may contain single or multiple probiotic strains, but the components label may specify which strains are present and whether they are alive and active.
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Even foods like “wheat, onions, bananas, garlic and leeks” can feed bifidobacteria into our energy, ”Prodam said.

Whether or not children have more probiotic strains may have genetic and environmental potential, Moore said – but even microbiota formation can be “directly dependent,” including changes in microbiota when eating over-processed foods.

“The most important thing is to eat a varied diet and avoid lots of processed foods,” Moore added. “The more processed foods you eat, the more likely you are to have a detrimental effect on the microbiome. It can lead to obesity but also potential (gastrointestinal) dysfunction and inflammatory conditions of the GI tract, such as Crohn’s disease.”

Unknown of probiotics

Additional, lengthy studies are needed to further understand how probiotic supplements can improve intestinal microbiota, and therefore metabolism and weight.

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“There’s already data that suggests that obesity (may be) associated with microbiome changes, although not a lot of data describes how microbiome changes came first … or weight changes and then microbiome changes.” Moran said in an email. “We also know that many major dietary changes (especially restricted diets) have a major impact on our microbiome.”

Despite the popularity of popular probiotic dietary supplements, many of them were introduced to the U.S. before hitting the shelves. Approval by the Food and Drug Administration is not required. Probiotics sold as drugs or treatments for certain conditions must first be proven safe and effective by clinical trials and approved by the FDA.

“Although probiotics are generally considered safe for most people, most probiotic trials do not report safety data strictly because these data are recorded in pharmaceutical trials,” said Dr. J. Frey Predis, a gastroenterologist and assistant professor in the Department of Pediatrics. Pediatricians at Baylor College of Medicine and Texas Children’s Hospital.

“So the risk of side effects may be higher than we thought,” added Prednis, who was not involved in the study. “Parents should consult their pediatricians before starting any probiotic practice.”

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