Melatonin probably. A good night’s sleep may have more uses than help. New studies from the Cleveland Clinic suggest that the hormone may be a possible treatment option for people infected with the novel coronavirus.
In an analysis of patient data from the Cleveland Clinic’s COVID-19 registry, the researchers found that melatonin, a hormone that regulates the body’s sleep-wake cycle, was associated with an approximately 30% reduction in a positive test for SARS-CoV-2. After adjusting the history of smoking and the comorbidities of various diseases, “said a news release with a study published in the journal Plus Biology. (SARS-CoV-2 is the virus that causes COVID-19.)
Melatonin probably. A good night’s sleep may have more uses than help. New studies from the Cleveland Clinic suggest that the hormone may be a possible treatment option for people infected with the novel coronavirus. (iStock)
The findings on melatonin are derived from the novel “Artificial Intelligence Forum” developed by Lerner Research Institute researchers to identify possible drugs for COVID-19 reconstitution.
More specifically, researchers in the study “used network drug methods and large-scale electronic health records of patients at the Cleveland Clinic to identify common clinical features and pathology among COVID-19 and other diseases.”
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Specifically, they measured proximity between host genes / proteins associated with 64 other diseases in several disease categories (malignant cancer and autoimmune, cardiovascular, metabolic, neurological, and pulmonary diseases), where proximity is indicative of pathological knowledge. Connections between diseases. ”
In severe cases, for example, respiratory distress syndrome and sepsis have been identified as the two leading causes of death in COVID-19 patients. The researchers found that the proteins associated with both of these conditions were “highly linked to multiple SARS-Co-2 proteins.”
“This indicates to us that the drug already approved for the treatment of this respiratory condition may also have some utility in treating the Covid-1 treat by acting on the shared biological targets,” said Fixing Cheng, Ph.D. Lead author on the clinic’s Genomic Medicine Institute and study, in a statement.
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By the end, the researchers found that autoimmune, pulmonary, and neurological diseases showed “significant network proximity to SARS-CV-2 genes / proteins and identified 34 drugs as repropose candidates, of which melatonin chief.”
That said, Cheng warned that the researchers’ findings do not suggest that people should start taking melatonin without consulting their physician.
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More research is needed, especially large-scale observational studies and randomized controlled trials, Cheng said, adding that they are “important for validating the clinical benefits of melatonin for COVD-19 patients.”
“Recent studies indicate that COVID-19 is a systemic disease that affects multiple cell types, tissues, and organs, so knowledge of the complex interplay between viruses and other diseases is essential for understanding COVID-19-related complications and identifying reproducible drugs. Is key. ” Cheng. “Our study provides a powerful, integrated network drug strategy to predict the manifestations of the disease associated with COVID-19 and facilitate the search for effective treatments.”
