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Some have suspected that changing the guidelines set by vaccine-producing pharmaceutical companies may affect the quality of the immune response. GPs have also noted that women who have a history of coronavirus infection are more likely to have side effects after vaccination. Therefore, some have doubts as to whether a translator should be vaccinated if I already have immunity after an illness. Who else to take the risk? After all, blood clots can form after a vaccine.
GPs have long noted that people with a history of coronavirus infection feel worse after vaccination, noting more significant side effects compared to those who have not. Researchers from the US National Cancer Institute and the National Heart, Lung, and Blood Institute have answered in sufficient detail why their immune systems respond to vaccines so much more actively.
Examination of antibody titers in more than 1000 patients showed that individuals with a history of coronavirus infection after the first vaccination with Pfizer-BioNTech or Moderna had the same high antibody titers as those without two vaccines with the same vaccines.
The results are in line with the findings of a study initiated by the Institute of Allergy and Infectious Diseases, which showed that after vaccination with a previous history of coronavirus infection, antibody titers (SARS-CoV-2 IgG) were up to 10-45 times higher than in the mRNA vaccine group, people who have not previously had COVID-19.
This confirms previous statements by researchers that SARS-CoV-2, even when the antibody titer is zero, triggers the T- and B-lymphocyte-induced immune memory of the previous agent, so the immune response is significant after the first vaccination. Therefore, the response to vaccination is always stronger in people with a history of coronavirus infection. They have a higher percentage of side effects.
And why women are more likely to report side effects after vaccination (which certainly shows a more active immune response to the vaccine, which is good in principle) can be explained very simply. After all, most of the genes responsible for immune system responses are located on the X chromosome. And women have two (XX) of them and therefore twice as many genes responsible for immune system response. . And men – XY.
Additionally, the capillary network in a woman’s shoulder muscles also appears to be more abundant, allowing the vaccine to enter the general bloodstream more quickly. And the question of whether vaccination is worth it if we’ve already had a coronavirus infection should probably be completely dispelled with long-established scientific evidence that reliable immunity develops for just 3 months after COVID-19, whereas the body’s immune protection against coronavirus (at least from severe clinical forms of disease and renovation rooms) is guaranteed for 6 months.
Some seem to have reasonable doubts as to whether a longer pause between the first and second vaccinations of three to six weeks can be given. Researchers from the pharmaceutical company Pfizer, who studied in detail the dynamics of antibodies between the first and second vaccines, said that the immune response did not suffer. Therefore, the question of whether it is possible to extend the intervals between the first and the second vaccination to 6 weeks, I believe, the researchers have answered.
It is understandable that each of us would like to receive a second vaccination after 3 weeks and get maximum immunity as soon as possible. Although the first vaccine with mRNA vaccines guarantees adequate protection. Yes, the US Centers for Disease Control and Prevention report that after the first dose, Pfizer-BioNTech or Moderna vaccines provide 80 percent protection against coronavirus. According to British researchers, 15 days after the first vaccination, the vaccine is as effective as 89-91 percent.
When it comes to vaccination issues, the topic of blood clots still seems to be very relevant to some people. Any new information, even based on scientific evidence, on the very rare possibility of clots forming after vaccination with the AstraZeneca vector (current name Vaxzevria) or the Johnson & Johnson vaccines may not be convincing.
The demonstrative vaccination of many European leaders with the AstraZeneca vaccine, the claims of scientists that the chance of a clot in flight is 500 times greater than the vaccine does not appear to have any effect.
Some people categorically refuse to get vaccinated with AstraZeneca due to lack of confidence in the vaccine. In-depth research on adenovirus-based vaccines has shown that in very rare cases (10 out of a million), autoantibodies can develop against platelets, leading to thromboembolic complications.
Is it a big risk? Apparently not. The risk of lightning is probably much higher, but we are not afraid to go outside. I believe that when all countries in the world feel a shortage of vaccines and the coronavirus pandemic shows no signs of disappearing easily, all approved vaccines are a scientific gift to humanity.
