But there are some key differences. Most importantly, the Moderna vaccine can be stored in a common freezer and does not require a super-cold transportation network, making it more accessible to smaller facilities and local communities.
While Pfizer is a pharmaceutical behemoth, modern – modified RNA. Is short for – is a biotech company based in Cambridge, Massachusetts.
The company’s scientists are already collaborating with researchers from the National Institutes of Health on a vaccine for another coronavirus called Middle Eastern Respiratory Syndrome (MERS). When Chinese researchers released the genomic sequence for the novel coronavirus in mid-January, they took a leap.
FDA green-lit clinical trials, the Moderna vaccine on March 3, outside the gate. Its state-of-the-art clinical trial began on July 27 and is being conducted in the U.S. The first government-funded phase 3 clinical trial for the Covid-19 vaccine was in. The company applied to the FDA on November 30 for authorization of emergency use for the vaccine.
Does the vaccine work?
The Modirna vaccine was effective in preventing the Covid-19 case and limiting the serious Covid-19 during the trial.
In the Modernna trial, 15,000 study participants were given a placebo, a saline shot that had no effect. Over the course of several months, 185 of them developed Covid-19, which had 30 severe forms of the disease. One of them died.
Another 15,000 participants were vaccinated, and only 11 of them developed Covid-19. None of the 11 fell seriously ill.
According to the briefing document, the vaccine was effective in participants with age groups, races, ethnic and racial groups, and participants with clinical comorbidities associated with high risk of severe covid-19. About 10% of the studies were black and 20% were Hispanic or Latino.
How does it work?
Moderna’s vaccine in particular contains a synthetic mRNA that codes for the formation of a virus known as a “pre-fusion stable spike glycoprotein.”
The vaccine contains fatty substances called lipids, tromethamine, tromethamine hydrochloride, acetic acid, sodium acetate and sucrose.
How is the modern vaccine different from Pfizer?
Appearing on CNN’s “New Day” on Tuesday, FDA vaccine advisory committee member Dr. “They look almost identical,” said Paul Fitte.
Structure: Both vaccines require mRNA or messenger RNA to work. Depends on, though with slightly different compositions and makeup.
“Although they are both messenger RNA vaccines, they are actually different messenger RNA molecules, they have different so-called lipid delivery systems, meaning they are sorted like a fatty dot located in messenger RNA,” they said on Monday. “That’s why they have storage and handling specifications.”
Cold storage: Most importantly, the modern vaccine does not need to be kept at extreme-cold temperatures, like Pfizer.
In contrast, the Moderna vaccine can be kept at about minus -20 degrees Celsius or at home freezer temperatures, according to Monsef Sloui, head of U.S. efforts to develop a vaccine for Covid-19. The Moderna vaccine can also be kept in the refrigerator for 30 days before it expires.
“So it’s more organized and much more commonly available,” Sloui said Tuesday.
These differences suggest that the Pfizer vaccine may be more useful for large organizations with established infrastructure such as hospitals, while the modern may be more useful for small facilities such as local facilities or pharmacists.
Dosage and time: The Moderna vaccine is given as two 100-microgram doses given at 28-day intervals. Pfizer vaccine 21 is given as two 30-microgram doses except 30 days.
Age: If authorized, the Moderna vaccine will be used in people 18 and older, whereas the Pfizer vaccine was authorized for people 16 and older.
Is it safe?
The vaccine has a “favorable” safety profile, the briefing document to the FDA said, adding that “there is no particular safety concern.” Which prevents him from getting emergency clearance.
The most common adverse reactions to the vaccine, according to the document, are injection site pain, fatigue, headache, muscle aches, joint pain and chills. Swollen lymph nodes have also been reported.
Overall, there was a “low frequency of non-fatal serious adverse events and without a meaningful imbalance” between the vaccine receiving group and the placebo receiving group.
When will I be able to get it?
Once the FDA approves emergency use, Soloi said shipments are expected to begin 24 hours after the vaccine arrives at the facility by Monday morning.
More than a million doses of Moderna vaccine will be sent to more than 200,500 sites, far more than the 6,636 Pfizer vaccine sites.
CNN’s chief medical correspondent, Dr. Sanjay Gupta speculated that the vaccine would normally be available in late spring or early summer.
CNN’s Jane Christensen, Elizabeth Cohen and Naomi Thomas contribute to the report.
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