| Cincinnati Inquiry
According to a new and comprehensive analysis by an organization representing seven of the country’s largest pediatric centers, black, Asian and Hispanic children are significantly worse than other children during epidemics tested and treated for VVID-19. The disease also hits poor children and people with diabetes and cancer, the analysis shows.
In addition, the analysis shows how children are more susceptible to the virus than adults. 1 out of every 25 children in the study (or 4% of the more than 135,000 participants) tested positive.
The findings from the PEDCenet Institute, which includes Cincinnati Children’s Hospital Medical Center and Nationwide Children’s Hospital in Columbus, were published Monday at JAMA Pediatrics. The report is based on electronic medical record data from children who were tested for SARS-Co-2 virus infection between January 1 and September 1, 2020.
Dr. Nat, a Cincinnati Children’s Pulmonary Medicine Specialist and one of the study’s 18 co-authors. “These findings are important because they improve our understanding of the effect of COVID-19 in pediatrics,” said Nathan Pajor.
“We find that children are more likely than adults to have a serious illness or to die from covid-1,” he said in a news release. However, we also consider the disproportionate infection rates between Blacks, Asians and Hispanics. Children as a clear goal of further study. “
At other PEDCenet centers at Children’s Hospital of Philadelphia; Children’s Hospital of Colorado; Children’s Health System Names; Seattle Children’s Hospital; And, St. Louis Children’s Hospital. Collectively, these centers care for about 25 million children a year.
Features of his analysis include:
- As with previous, small studies, these data show that children are less likely to be positively tested when infected and less likely to develop a serious illness.
- Patients of African-American, Hispanic, and Asian descent are less likely to be examined than white children. However, they are two to four times more likely to test positive.
- Adolescents and young adults were more likely to test positive than younger children.
- Children covered by Medicaid and other public programs are more likely to have a positive test than children from privately insured families.
- Underlying cancers, diabetes (types 1 and 2), and other immunodeficiency conditions were signs of increased risk of serious disease. But children with asthma have not been found to have a higher risk of serious illness.
- Of the 5,374 children who tested positive, about 1 in 14 (or 7%) required hospitalization. Of those hospitalized, 28% required intensive care and 9% required mechanical ventilation. Of the children admitted to the hospital, eight died. (That’s a 0.2% case.)
“More studies are needed to understand the reasons behind the variability in positivity rates,” Pajore said. “How relevant the risk is to social determinants, such as exposure to air pollution, density of accommodation or the likelihood of living with a person who must work in a personal job. How much does the difference in the biology of the disease reflect? “
Another co-author of the Cincinnati Children’s was Janet Jahner, the chief data warehouse analyst there.
There are limitations to the study. This does not include some children who were infected or potentially killed by COVID19 due to lack of test availability. Presumably it underestimates the actual number of asymptomatic infected children across the country and does not take into account what risks these children pose to adults in their lives. The study also offers no insight into the long-term consequences of novel coronavirus infection.
Finally, the study focuses on the chaotic nature of the early days of the epidemic and how to deal with specialists in the most serious complications affecting children.
Initially children who experienced severe adverse inflammatory reactions were diagnosed with Kawasaki disease, a very rare condition, mostly for unknown reasons. As physicians noted the difference between new cases and older ones, the diagnosis turned into a disease like Kawasaki. It has since evolved into “childhood multisystem inflammatory syndrome” (MIS-C).
The patient-centered outcome research was paid for by a nonprofit created by the Affordable Care Act (also known as Obamacare).
Associate Director of the Cincinnati Children’s Research Foundation, Dr. The PEDCenet Data Coordinating Center is located in Philadelphia, but the idea behind PIDNET, which launched in 2014, was a national cooperative effort among its co-founders, says Tracy Glauzer.
“Part of the challenge for pediatric research has been that many of our conditions are so rare that a single organization does not have enough information to address specific issues in detail,” says Glauser. “PEDCenet’s goal is for organizations to work on ways to answer data sharing questions that we don’t address alone.”
Cincinnati Children’s Leaders have invested years in launching a number of data-sharing initiatives, including the Genomics Research and Innovation Network (GRIN), which became the Data Coordinating Center for the Bench to Basinet (B2B) program for cardiac research in 2016. . Rare Diseases in 2019 has been named as the Data Coordinator for the Clinical Research Network (RDCRN).
Dr. Peter Margolis, James M., acting chief investigator of the Cincinnati Children’s Site for PEDSnet. Anderson is co-director of the Center for Health System Excellence and has an extensive track record in the building network for improving and researching the quality of health care.
“PEDCenet provides a national digital architecture that can use the power of electronic health records to advance knowledge.” “Without PEDCenet, it would have taken many years to gather the information we are presenting today.”
The participating medical centers have overcome enormous technical challenges to building a tracking system early in the epidemic. Now, as the epidemic continues, the data can be quickly refreshed to allow for .d analysis.
“Effective response to SARS-Cavi-2 will require rapid but robust development of new clinical and public health practices based on a better understanding of viral and host biology,” the co-authors said in their analysis. “This knowledge will be important not only in caring for critically ill patients, but also in creating sustainable ways to reduce the burden of disease caused by SARS-COV-2.”
