Banner, SE, Wahl, GM and Von Hoff, DD Dual minute chromosomes and together in staining regions, tumors are taken directly from patients in the human tumor cell line. Anticancer drugs 2, 11-25 (1991).
Turner, KM et al. Extrachromosomal oncogen amplification drives tumor development and genetic heterogeneity. Nature Held at 543, 122–125 (2017).
Albertson, DG Gene Amplification in Cancer. Trends Genet. 22, 447–455 (2006).
Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of Alt, FW, Calams, RE, Bertino, JR, and Shimke, RT Sanskrit murine cells. J. Biol. Chemistry. 253, 1357–1370 (1978).
Kaufmann, RJ, Brown, PC, and Shimke, RT-amplified dihydrofolate reductase genes in unstable methotrexate-resistant cells are associated with double-minute chromosomes. Proc. Natal Acres. Science. USA 76, 5669–5673 (1979).
Nunberg, J.H., Kaufeman, R.J., Shimke, R.T., La Ralab, g. And chasin, LA amplified dihydrofolate reductase genes methotrexate-resistant Chinese hamsters are uniformly localized in the ovary cell line in a uniformly staining region of the same chromosome. Proc. Natal Acres. Science. USA 75, 5553–5556 (1978).
Carroll, S.M. Et al. Double minute chromosomes can be produced by precursors arising from chromosomal casting. Mall. Cell. Biol. 8, 1525–1533 (1988).
Ruiz, Jesse and Wahl, GM chromosomal instability during gene amplification. Mall. Cell. Biol. 10, 3056–3066 (1990).
Cockwell, A., Rosier, L., Duterilex, b. And Debtis, m. The inclusion of multiple double-strand breaks in an hour by magnuclease I-SCI expression or delicate site activation leads to double minutes and other chromosomal rearrangements. Oncogen 21, 7671–7679 (2002).
Nathanson, DA et al. Therapeutic resistance targeted by dynamic regulation of extrachromosomal mutant EGFR DNA. Science 343, 72–76 (2014).
ICGC / TCGA pan-cancer analysis of the entire genome consortium. Pen-cancer analysis of the whole genome. Nature Held at 578, 82-93 (2020).
Lee, y. Et al. Examples of somatic structural diversity in the human cancer genome. Nature Held at 578, 112–121 (2020).
Cortes-Syriano, i. Et al. Comprehensive analysis of chromosomes in 2,658 human cancers using full-genome sequencing. Net. Jeanette. 52, 331–341 (2020).
Stephens, PJ et al. Giant genomic rearrangement acquired in a catastrophic event during the development of cancer. Cell 144, 27-40 (2011).
DiCarvalho, AC et al. Incompatible inheritance of chromosomal and extrachromosomal DNA elements contributes to the development of dynamic disease in Giloblastoma. Net. Jeanette. 50, 708–717 (2018).
Varhak, RGW, Bafna, V. And Mitchell, P.S. Extrachromosomal oncogen amplification Tumor pathogenesis and evolution. Net. Rev. Cancer 19, 283–288 (2019).
Russ, T. Et al. Genome sequencing of pediatric medulloblastoma combines catastrophic DNA rearrangements with TP53 mutations. Cell Held at 148, 59–71 (2012).
Nons, k. Et al. Esophageal adenocarcinoma and drive tumorigenesis often produce genomic destruction. Net. Commune. 5, 5224 (2014).
Ltd., p. Et al. Chromosome segmentation errors create a diverse spectrum of simple and complex genomic rearrangements. Net. Jeanette. 51, 705–715 (2019).
Singer, MJ, Mesner, LD, Friedman, CL, Tresc, BJ, and Hamelin, JL Human dihydrofolate reductase genes are initiated by double-minute expansion, chromosome breakdown. Proc. Natal Acres. Science. USA 97, 7921–7926 (2000).
Windle, B., Draper, BW, Yin, YX, O’Gorman, S. And Wahl, G.M. Central role for chromosome breakdown in gene amplification, deletion formation and amplification integration. Genus god. 5, 160–174 (1991).
McClintock, b. Stabilization of broken ends of chromosomes in Xia Mess. Heredity 26, 234–282 (1941).
Glodzick, d. Et al. The somatic-transformation process replicates the susceptibility of shoots in breast cancer to loci and tissue-specific super-enhancement. Net. Jeanette. 49, 341–348 (2017).
Garsed, DW et al. Architecture and evolution of cancerous neochromosomes. Cancer cell 26, 653–667 (2014).
Landry, JJ et al. Genomic and transcriptomic landscape of the Hela cell line. G3 (Bethesda) 3, 1213–1224 (2013).
Zhang, CZ et al. Chromothripsis due to DNA damage in the microclay. Nature 522, 179–184 (2015).
Yaeger, R. Et al. Acquired resistance mechanisms for BRAF V600E inhibition in colon cancer coordinate on RAF dimirization and are susceptible to its inhibition. Cancer. 77, 6513–6523 (2017).
Ltd., p. Et al. Selective Y centromere inactivation causes chromosome dispersion in the micronuclei and improves by joining non-homologous endings. Net. Cell biol. 19, 68-75 (2017).
Shimizu, N., Hashizum, T., Shingaki, K. And Kwamoto, J.K. The acquisition of plasmids has a mammalian replication initiation field, with a controllable conflict between replication and transcription. Cancer. 63, 5281–5290 (2003).
I.e. Kijoski, J., Lee, Y., Bosco, N., Campbell, P.J. and D. Lange, T. Induced by chromothripsis and catechu telomere crisis. Cell 163, 1641–1654 (2015).
Hofelder, DR et al. Resolution of anaphase bridges in cancer cells. Chromosoma 112, 389–397 (2004).
Hallede, T., Peterman, E., London, C., Hodgson, b. And Sharma, K.N. R.A. as treatment targets. DNA repair route. Net. Rev. Cancer 8, 193–204 (2008).
Sermac, t. Et al. Efficient design and assembly of custom TALEN and other TAL effect based constructions for DNA targeting. Nucleic acids res. 39, e82 (2011).
Fachinetti, d. Et al. The DNA sequence-specific binding of CENP-B increases the loyalty of human centromere function. God. Cell 33, 314–327 (2015).
Schindelin, j. Et al. Fiji: An open source platform for bio-image analysis. Net. Methods 9, 676–682 (2012).
Oh, HD et al. Chromate: Visualization of 3D chromatin structure and interface and compaction in mitotic cells. Science Is 357, eaag0025 (2017).
Visualizing viral protein structures in cells using genetic probes for Uch, HD, Dirink, TJ, Bush, Ng, E., Ellisman, MH and O’Cia, CAClated light and electron microscopy. Methods 90, 39-48 (2015).
Rao, SS et al. A 3D map of the human genome in kilobase resolution demonstrates the principles of chromatin looping. Cell Is 159, 1665–1680 (2014).
Ltd., h. And Durbin, r. Fast and accurate long-reading alignment with Burrows-Wheeler transform. Bioinformatics 26, 589–595 (2010).
Raine, KM et al. ascatNgs: Identify somatly acquired copy p-number changes from full-genome sequencing data. Cure Protoc. Bioinformatics 56, 15.9.1–15.9.17 (2016).
Nick-Zainal, s. Et al. 560 Breast cancer Landscape of somatic mutations throughout the genome sequence. Nature Held at 534, 47–54 (2016).
PJ criteria for predicting chromothripsis in the cancer genome by Joe and Campbell. Cell 152, 1226–1236 (2013).
Lee, y. Et al. Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukemia. Nature 508, 98–102 (2014).
Alexandrov, LB, Nick-Zainal, S., Wedge, DC, Campbell, PJ and Stratton, MR Dissecting signatures, .Peractive of mutations in human cancer. Cell representative. 3, 246–259 (2013).