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Original Title: Olympus Optical Microscopy Technology Helps Reverse Hearing Loss
Deafness is a common auditory neurological disorder. According to the latest data from the World Health Organization, approximately 466 million people around the world are hearing impaired. Hearing loss is mainly due to damage to the sensory hair cells of the inner ear. To help people who have lost their hearing hear the world again, Olympus’ sophisticated and professional microscope products help life scientists study and understand at the molecular level Hearing problems provide reliable support.
The progress of cell research is inseparable from the support of advanced microscopy technology. As a leading manufacturer of life science microscopes, Olympus has continuously applied various advanced optical technologies since the arrival of the first “Asahi” microscope in 1919. In the life sciences field, upright, stereo, inverted, confocal microscope systems , multiphotonics and super-resolution were developed to provide innovative optical solutions for many applications.
High magnification for easy molecular-level observation
For life scientists, understanding how hair cells work and determining whether they can regenerate may be the key to reversing deafness. Therefore, most of the work done in the sensory neuroscience laboratory involves stimulation, observation, and analysis of hair cells at high magnification to extract detailed structural information.
With the rapid advancement of optical imaging research technology, high-resolution, high-magnification microscopes have become a powerful engine for promoting cell biology, neurobiology, and other life science research. Under the great innovation of Olympus optical technology, the technical upgrade of the microscope objective system makes the observation of high-precision structures more clear. Among them, Olympus launched the NA 1.7 APON100XHO TIRF objective lens for intracellular molecular imaging, which successfully surpassed the resolution limit of traditional light microscopes, allowing users to easily cope with single-molecule dynamic research and the ultra high resolution research.
As a contributor to hearing loss research, James Hudspeth dedicated his life to studying and understanding hearing problems at the molecular level. Currently, James and his team have 10 Olympus microscopes that can be used full time. Speaking about choosing Olympus optical microscopes for scientific research, James said: “The team started using Olympus microscopes 25 years ago. There are two main reasons why Olympus microscopes have been used. First, Olympus” The quality of Bass microscopes is excellent: the manufacture of instruments, lenses and all the parts is excellent. Second, and most importantly, Olympus is always willing to listen to our special product needs and through enhancements that allow us to do our jobs better. . “
James Hudspeth uses an Olympus microscope to study hair cells in the inner earContinuous real-time observation to understand mutation genes that can cause hearing loss
Medical research has shown that mutations in more than 200 genes in the human body can cause hearing loss. Using a microscope to look at damaged cells and determine how damage occurs to try to understand such mutations has always been an important scientific research topic that scientists are committed to investigating and solving.
In the molecular biology field of genetic research, the Olympus fluorescence microscope is equipped with a high-quality, high-performance optical system that can focus for a long time to observe stable intracellular dynamics and provide high-performance time series images. precision. Intuitive imaging software can provide simple system operation for various molecular biology research applications (including in situ analysis) and further support researchers to further explore the field of molecular biology.
James Hudspeth’s team uses a microscope to study genetic mutations related to hearing lossSharing the research results, James said that in the process of searching for possible drugs for hair cell regeneration, the Olympus microscope team has examined more than 80,000 compounds and found six seemingly reasonable methods, one of the Which method is very effective in promoting the division of supporting cells (cells that can become hair cells).
With the advancement of microscopy technology, more and more mysteries of life have been uncovered, and it is believed that people with hearing impairments will hear the beauty of the world again in the near future. “To achieve health, tranquility and happy lives for the people of the world” is the corporate mission that Olympus has always insisted on. Being able to benefit human health with the majority of scholars of scientific research is an inexhaustible driving force for the development and growth of the company. In the future, Olympus will continue to study and innovate to continually innovate microscopic technology and products and contribute to the great chapter of human health.
