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Original title: Gao Fu: The third phase of the new corona inactivated vaccine is expected to clear up next month, and the challenge of the epidemic will be more severe this winter.
On the afternoon of October 28, at the 15th International Conference on Genomics (ICG-15) held in Wuhan, Gao Fu, an academic at the Chinese Academy of Sciences and director of the Chinese Center for Disease Control and Prevention, awarded the title “COVID-19 Challenge and Opportunity for Global Public Health.” “(” New Coronary Pneumonia: Challenges and Opportunities for Global Public Health “) keynote address.
Image: Gao Fu is giving a speech at ICG-15. ——Photo by a 21st Century Business Herald reporterGao Fu pointed out in his speech that the new coronavirus is a challenge and an opportunity for human public health. After the outbreak in Wuhan, the most critical problem is finding the virus, analyzing the sequence to see what virus it is and how to isolate it.
In response to the current epidemic situation, Gao Fu said: “At present, there have been seven waves of epidemics in China, followed by Wuhan, Northeast, Beijing, Urumqi, Dalian, Qingdao and Kashgar. In China, all waves of epidemics have been controlled. Okay, so each wave can be seen clearly and plainly. However, due to poor control of the epidemic in Europe and the United States, there is no obvious wave. Now it’s the second wave, but it’s actually the first. The wave is not over yet. “
Gao Fu mentioned at the meeting that the three most critical things in fighting the epidemic are: wearing a mask, keeping your distance and paying attention to personal hygiene, such as washing your hands frequently.
01 Responding to some queries
In response to some doubts from the outside world, Gao Fu responded to the cyber conspiracy theory attack from Event 201.
On October 18, 2019, the Johns Hopkins Center for Health Security in the United States, in cooperation with the Gates Fund and the World Economic Forum, simulated a tabletop exercise of the global plague epidemic. The meeting simulated a coronavirus called CAPS, It is more deadly than SARS and easier to spread than the flu. There is no vaccine available and it spreads worldwide in 6 months. The exercise was called Event 201, and 15 government, business and public health leaders were invited to participate to exercise how to make decisions between the different policy options under the epidemic.
Gao Fu said that this exercise is very close to the time of the new corona epidemic, and the development path is very compatible. At the time, the meeting also provided a number of suggestions for dealing with potential epidemics, including that the government should strengthen capacity to use large companies, lean resources for vaccine research and development, and be financially prepared to deal with to the epidemic. Gao Fu mentioned that for industry insiders, the new corona epidemic is a gray rhinoceros event (referring to a potential crisis with high probability and high impact). Unfortunately, while Event 201 predicted the future, it did nothing to help fight the epidemic. The gray rhinoceros incident in the eyes of the professionals became the black swan incident in public life, and the unsuspecting public paid a huge price for it.
Gao Fu emphasized that because the new coronavirus is widespread in nature and recombination is common, the most important thing is to establish a monitoring network. “There is COVID-19 today. I can responsibly tell you that there will be COVID-29 and COVID-39 in the future. Like influenza viruses, these viruses are already very close to humans.”
In a speech on the second day of the conference (October 27), researcher Shi Zhengli from the Wuhan Institute of Virology noted very cautiously that bats are the natural host of SARS-CoV-2 (novel coronavirus), but the route transmission and the intermediate host need to be further studied. .
In this regard, Gao Fu said in his speech: “At first we suspected that it came from animals, but 10 months have passed and so far no animal reservoir of the new coronavirus has been found.”
Gao Fu said that his team, along with Shi Zhengli’s team, discovered that ACE2 is the receptor for SARS-CoV-2 (novel coronavirus). The article was published in Cell and should have its own name. At that time, the national public opinion questioned his inadequate prevention of the epidemic, but responded very quickly to the publication of the article, after the final article was sent, it did not have his signature.
“But everyone knows that this is our team (the work done), to show that their (new coronavirus) receptor, like the SARS virus, is ACE2,” Gao Fu added.
02 A series of vaccine problems to solve
Currently, the most critical issue for the new corona epidemic is vaccines. In late July, Gao Fu said that he had been injected with a new corona vaccine.
In his speech, Gao Fu said: “Currently, China has 4 vaccines entering phase III clinical trials, including two inactivated vaccines developed by China Biotech, an inactivated vaccine developed by Kexing Biotech, andCansinoAn adenovirus vaccine developed in conjunction with the Academy of Military Medical Sciences. The Chinese Center for Disease Control has participated in two inactivated vaccines, namely China Biotech and Kexing Biotech. “
He said: “Everyone knows that China’s inactivated vaccines go very fast. This is because fire vaccines require P3 laboratories, which foreign companies do not need. In China, the Chinese Center for Disease Control has two P3 laboratories “. With loans for China Biology and Kexing Biology, the cooperation started in early February. The Wuhan Institute of Virology has loaned its P3 lab to the Wuhan Institute of Biological Products, so China has taken the lead in inactivated vaccines. “
For the inactivated vaccine that is undergoing phase III clinical trials in the Middle East, Gao Fu said he hopes to stop blinding by the middle of next month. By then everyone will know how effective the new corona inactivated vaccine is.
Earlier, many people in the industry pointed out to 21st Century Business Herald reporters that among current vaccine routes, fire vaccines have the best hope. As a variety of new corona vaccines enter the phase III clinical stage, some opinions suggest that the ADE effect may be a potential risk from the new corona vaccine.
ADE effect, namely “antibody dependent enhancement” (antibody dependent enhancement). It refers to specific antibodies to certain viruses that bind to the virus and instead introduce the virus into the cell, causing a more serious infection.
In response to this, Gao Fu believes that whether the new corona vaccine has an ADE effect, whether the ADE effect will affect the use of the vaccine or whether it is necessary to wait until phase III clinical results are available before making a judgment. .
Can neutralizing antibodies play a protective role? What is the neutralizing antibody titer to protect? Gao Fu said that he did not know this. If there are neutralizing antibodies, how long can they last in the body? Is there ADE (antibody dependent effect)? “I don’t know. In short, a series of questions cannot be answered.” Gao Fu said: “Before the vaccine is mature, it will be reserved for the first line and people who need to maintain daily life.”
Now that winter has come and the flu is coming, is it possible for pneumonia to return? “We have a great challenge,” Gao Fu said.
Gao Fu said that the virus can survive for a long time in a dark and humid environment. It cannot be ruled out that some of the first viruses in Wuhan are still hidden in a dark and humid environment. Gaofu warned that we will face a more severe test. Especially this winter, either the flu or the new corona epidemic that may be mixed in, will cause fever.
(Author: Tang Wei Ke)
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