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PHOTO: Reuters
Spanish physicians studied in detail the process of thrombus formation in the coronary artery of patients with the most severe forms of Kovid-19 and concluded that they occur as a consequence of
excessive activity of immune cell neutrophils, reported TASS, cited by BTA. The results of the study and possible methods to combat blood clots are published in the journal JAMA Cardiology (Journal of the American Medical Association).
Our observations have shown that so-called neutrophilic extracellular traps play an important role in the formation of thrombi in coronavirus carriers and in the development of myocardial infarction. This suggests that targeted exposure to these cells will prevent thrombus development. in the coronary artery in patients, ”write the study authors.
The SARS-CoV-2 virus infection leads to the development of serious immune disorders, massive inflammation, thrombus formation, and other life-threatening problems in the heart and blood vessels. Scientists are trying to understand why these disorders occur and how to prevent them.
In late May, French cardiologists discovered that infection with the new coronavirus was accompanied by an increased risk of developing venous thrombosis in patients with severe Covid-19. Russian doctors came to similar conclusions, finding that severe infections were associated with an increase in the concentration of D-dimer, a protein that is produced during the breakdown of fibrin.
Spanish doctors led by Anna Blasco, a cardiologist at the Hospital de la Universidad Autónoma de Madrid, found that all blood clots taken from the coronary arteries of seriously ill patients with Covid-19 contained unusually high levels of neutrophils. According to Blasco and his colleagues, the work of neutrophilic extracellular traps in severe forms of coronavirus infection is interrupted and leads to the fact that they begin to attack not only the causative agent of the disease, but also platelets. This leads to the spontaneous formation of blood clots in the blood vessels, including the coronary artery, which in some cases leads to a myocardial infarction.
This problem can be avoided by reducing the number of neutrophils in the patient’s body or by avoiding the formation of many neutrophilic extracellular traps in the blood. The researchers plan to conduct experiments soon to test their theory and prevent patients from developing blood clots in the heart.
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