Modern vs. Biontech: What is the difference between the two corona vaccines?

After the successfully tested vaccine from the German company Biontech, the American company Moderna is now sending another hope-bearer on the run. The question arises: which of the two looks more promising in the fight against Corona?

According to the Federal Ministry of Education and Research There are currently around 200 Corona vaccine developments underway around the world. Two of these vaccines are already in the last of the three mandatory clinical trial phases. About the vaccine BNT162b2, developed by Biontech in collaboration with the American pharmaceutical giant Pfizerlt, a first interim analysis of the test results was presented on November 9. On November 16 Moderna also published its provisional results Series of tests with your mRNA-1273 vaccine. The 1273 mRNA serum appeared to be even more effective than BNT 162b2, although experts tested positive here we were surprised. Meanwhile, on November 18, Biontech reports an even higher value.

Both companies are working hard on the final completion of their studies so that the rush approval process can start as quickly as possible, probably in the US first.But how exactly do these two preparations work? And what are its advantages and disadvantages?

On the video: Are Dog Owners at Higher Risk for Corona?

Our most read articles

northnew ways of vaccine development

METERWith their vaccines, both companies have broken new ground in vaccine development. Until now, conventional vaccines have also contained the pathogen, that is, the virus itself, in the form of so-called killed vaccines, that is, killed viruses or live vaccines that contain small amounts of weakened virus. If the immune system comes into contact with pathogens, it learns to recognize them based on the external structure and then forms suitable antibodies that can then recognize and block the live virus.

However, in rare cases, infection also occurs with live vaccines.s-symptoms, before the immune system can intervene. Both companies wanted to avoid this with their vaccines, also with regard to the main risk groups to be vaccinated, namely the elderly and people with previous illnesses.

Here you can find the latest news on the development of the lockdown situation.

background

Current information and frequently asked questions about the coronavirus
Merkel on tightening the blockade: “I could have imagined it”

Here you can find out what you need to know about the coronavirus and Covid-19. We keep an eye on the news that is most important to you and separate the important news about Sars-CoV-2 from the less important.

GRAMfragments instead of viruses

BNT162b2 Y MRNA-1273 they are the so-called mRNA vaccines. Both contain short sequences of virus genes, Messenger RNA, that is, those that are responsible for the formation of certain parts of the virus envelope, but do not trigger an infection. These sequences are “read” in the body. The shell particles with their characteristic barbed structure are also of the body’s own proteins educated. The immune system reacts to this by forming the appropriate antibodies, which after recognize and fight the whole virus.

reModern vaccine scores in terms of durability

reVaccines differ from each other in several respects, despite the common principle. BNT162b2n leaves gene sequences in their natural form. According to “sueddeutsche.de”, the modern vaccine supplements it with a “synthetic booster”. RE.This one is particularly remarkable in terms of shelf life and storage. The Biontech vaccine should be stored at minus 70 degrees. That could be a problem, especially in structurally weak regions and countries.

According to Moderna, 1273 mRNA serum is much more stable and can be stored in a normal refrigerator for 30 days. According to the information, it even survives twelve hours at room temperature without losing its effectiveness. If these statements are correct, this would be a great advantage in practice, as billions of people around the world must be vaccinated.

Here the volunteers report on their experiences after the vaccination test.

background

Corona vaccine
“Hangover and pain”: Vaccine evaluator reports how he was doing

There is great hope that an effective coronavirus vaccine will be approved soon. The vaccination has passed the testing phases. A volunteer now describes his experiences after a vaccination test.

Both vaccines proved highly effective in the test.

Both vaccines consist of two doses each am Distance of three (BNT162b2north) or four weeks (mRNA-1273). The next immunization process is completed approximately 30 days after the second vaccination for both agents, provided the serum works.. It is not yet known how long immunity lasts for either vaccine.

BNT162b2north It was administered to 43,500 volunteers in 120 research centers around the world and reached 90 percent effectiveness as announced on November 9. On November 18, this number was even corrected by up to 95 percent. The 1273 mRNA serum was tested in 30,000 people at 100 centers in the US and, based on findings to date, reached 94.5 percent. The number of volunteers in both groups also includes the prescribed control group of placebo subjects.

Noisy “aertzteblatt.de ” the proportion of volunteers from risk groups, that is, the elderly and people with previous illnesses, was significantly higher in the Moderna study than in the Biontech study, but it is not quantified precisely. Both vaccines showed on average only a few mild side effects, occasionally mild flu symptoms, headache and body aches, fatigue and pain at the vaccination site.

According to the latest data, both candidates are now roughly on par with the immunization quota. Small changes are still possible here. It also remains to be clarified whether the vaccines protect against the disease or the infection itself. This question is crucial, among other things, to make statements about whether people who have been vaccinated can still transmit the disease.

STAR RECOMMENDATIONS FOR YOU

Get all the news about your stars instantly by following them!