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Vietnam is conducting a Covid-19 trial vaccination in clean monkeys, marking a new big step in the research and development of this vaccine.
According to Dr. Do Tuan Dat, President of Vaccine and Biological Products One Member Limited Company (VABIOTECH), this unit has started testing the Covid-19 vaccine in monkeys since October 27.
The vaccine will be tested on the macaque variety macaca mulatta in Dao Reu (Quang Ninh). Mr. Dat said that the monkey selected for the test was a clean monkey, caught from a wild herd on the island, 3 to 5 years old, weighing around 3 kg. After trapping the monkeys, they will be kept in cages for a while and their health will be monitored. Once there is no disease, overalls can be used to test the vaccine.
Twelve healthy monkeys were selected to participate in two trials of the Covid-19 vaccine. Each wave was divided into 2 groups: vaccinated and a control group (not vaccinated).
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| Covid-19 vaccine study at VABIOTECH |
The vaccines used for preclinical testing of monkeys will have a model that is almost identical to that given to humans. The vaccine consists of 2 injections, the first between 18 and 21 days after the second. After the injection, the monkeys will be raised on a separate island and their health will be monitored on a daily basis.
After 1 month from the last injection, the experts will evaluate the immune response in the group of monkeys injected. The objective is to evaluate the immunological efficacy between the vaccinated group and the group that did not.
However, Mr. Dat also emphasized that testing vaccines in monkeys is only part of the preclinical trial. This unit will perform parallel tests on other animals and will perform laboratory analysis prior to clinical trials.
“You need to rely on a large amount of data and registries to have sufficient evidence of the safety, protective efficacy and immunogenicity of the vaccine, then it can be tested in humans,” Dr. Dat emphasized.
If the immunogenicity and protective effect of the monkey are successful, in about 4 months, the Vabiotech company will submit to the Ethics Committee of the Ministry of Health.
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| VABIOTECH tested the Covid-19 vaccine in mice |
Currently in Vietnam, there are 4 units involved in Covid-19 vaccine research and production, including the Institute for Vaccines and Medical Biological Products (IVAC), Vaccine and Biologicals One Member Company Limited (VABIOTECH). , Research Center for the Production of Vaccines and Medical Biological Products (POLYVAC), NANOGEN Pharmaceutical Biotechnology Co., Ltd.
Before any vaccine is widely available in the community, it must go through a standard 5-stage process:
1, Research, evaluation and selection of vaccine recruitment. This phase is carried out entirely in the laboratory.
2, Preclinical evaluation in animals.
3, Clinical evaluation through 3 stages in humans at different scales.
4, Vaccine circulation license.
5, follow-up after license. After the vaccine is licensed for human use, researchers will continue to monitor and evaluate to ensure that the vaccine is safe enough for use in humans.
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The Ministry of Information and Communications and the Ministry of Health agreed to implement a Bluezone application throughout the country to help prevent and control the Covid-19 epidemic. This application helps to warn users if they have accidentally been in contact with people infected with Covid-19.
To receive alerts from Bluezone, the first thing you need to do is download and install this application.
Link download Bluezone on Android Link download Bluezone on iOS
Once installed, users must give the Bluezone application permission to access storage and the Bluetooth connection to receive alerts from the application.
