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Bach Mai Hospital, Ministry of Health, WHO had to work very urgently to be able to bring 2 vials of antidote from Thailand to Vietnam in 10 days.
According to Dr. Nguyen Trung Nguyen, director of the Poison Control Center at Bach Mai Hospital, the unit is receiving inpatient treatment for a botulinum poisoning couple after using Pate Minh Chay. 2 patients are in very serious condition.
At the time of admission to Bach Mai hospital, the husband completely paralyzed the muscles from head to toe, could not breathe, had to depend on the ventilator. The wife is lighter, but also has all the muscles, cannot sit alone, has little cough, cannot eat alone, the risk of respiratory failure.
Dr. Nguyen said that two vials of antidote were quickly transported from Thailand to Vietnam by air for a timely emergency in these two cases.
Canada manufactures this drug, Botulinum Heptavalent Antitoxin (BAT), specifically to detoxify botulinum. The selling price of each bottle of this medicine in Thailand is up to 8,000 USD (about 185 million VND).
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| Heptavalent botulism antitoxin was transported from Thailand to Vietnam for emergency treatment |
Mechanically, BAT provides a passive immune response to the body through the antibodies it possesses, according to the US Food and Drug Administration.When injected into humans, these antibodies will bind tightly to free botulinum, causing it to already they do not interact with the nerve cell receptor.
Thanks to this mechanism, the drug helps to significantly reduce the phenomenon of paralysis, muscle weakness in patients with botulinum poisoning. Detoxified patients will reduce the risk of serious complications requiring mechanical ventilation.
Dr. Nguyen emphasized that cases of Botulinum poisoning are very rare in our country. Botulinum Characteristics is very toxic to the nerve, causing paralysis of all muscles, prolonged paralysis. In severe cases, the patient must be on mechanical ventilation for an average of many months and for the next several months to recover.
“For botulinum poisoning, if there is no antidote, the patient’s recovery time will be very long because he has to wait for the body to regenerate. In such challenging circumstances, we immediately thought of using an antidote for the patient. “ – Said the director of the Poison Control Center.
Mr. Nguyen also shared that because botulinum poisoning is so rare, drug companies rarely produce antidotes because profits cannot be guaranteed. Therefore, the heptavalent antitoxin of botulism, as well as the treatment of some other rare diseases, has its own storage mechanism.
“Countries tend to have a stock of rare drugs, concentrating drugs from different medical branches. When there are patients, the drug will be coordinated with hospitals, provinces or possibly with other countries “ – Shared Dr. Nguyen.
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| Male patient with botulinum poisoning being treated at Bach Mai Hospital |
Through regular exchanges in professional anti-poisoning associations, doctors at the Bach Mai Hospital Poison Control Center obtained the information that Thailand has registered cases of botulinum poisoning and that their country has stocks of antidotes. This poison.
In order to return the drug to Vietnam in the shortest possible time, Dr. Nguyen and his colleagues immediately contacted the Poison Control Centers of Thailand and coordinated with the Ministry of Health and the Organization of the Health. The world in Thailand and Vietnam.
“We have to make sure we get the necessary documents as quickly as possible. All stakeholders are very active in bringing these 2 medicine bottles to Vietnam.
Hospital, Ministry of Health tried to handle urgent procedures; WHO meets twice a day; Stakeholders communicated continuously through group emails. Thailand and Vietnam are also frequently connected by long distance calls. Everyone has a hard time “, Dr. Nguyen shared.
After 10 days of time trial races, 2 vials of heptavalent botulism antitoxin began to be shipped from Thailand to Vietnam on 27 August. The drug is strictly stored in a refrigerated box, in accordance with vaccine standards. Inside the box there is a thermometer to monitor the temperature.
On the afternoon of August 27, the drugs reached Vietnam. The patients received an antidote that same night.
Nguyen lien
Botulinum poison in Pate Minh Chay case is ‘the number one most famous poison’
Botulinum is considered “the most notorious poison in the world”, it is estimated that it is 10,000 times more powerful than the extreme poison potassium cyanide, even more dangerous than the radioactive element “most powerful planet”.
The Ministry of Information and Communications and the Ministry of Health agreed to implement a Bluezone application throughout the country to help prevent and control the Covid-19 epidemic. This application helps to warn users if they have accidentally come into contact with people infected with Covid-19.
To receive alerts from Bluezone, the first thing you need to do is download and install this application.
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Once installed, users must give the Bluezone app permission to access the Bluetooth connection and storage to receive alerts from the app.
