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A temporary national blockade will be established in Wales, Welsh Prime Minister Mark Drakeford announced.
The Welsh government believes that a two-week lockdown, or firewall, starting at 6pm on Friday is vital to help control the virus.
Around 2.3 million people in Wales already live under local lockdown rules: 15 of the 22 counties in Wales plus Bangor and Llanelli.
The Labor-led Welsh government has also banned people from traveling to Wales from Level 2 and Level 3 areas in other parts of the UK.