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Coronavirus was the third most common cause of death in England and Wales in October, not having been in the top 10 causes of death in the previous month.
The Official of National Statistics (ONS) has said that 3,367 (7.8%) of the 43,265 deaths in England last month involved COVID-19.
There were also 2,713 more deaths in England than the five-year average for October.
In October 2,992 deaths were recorded in Wales, 258 more than the five-year average.
Figures from England and Wales show death rates from coronavirus deaths have risen for the second month in a row.
The age-standardized death rate for deaths due to COVID-19 in October was 63.5 deaths per 100,000 people in England and 81.9 deaths per 100,000 people in Wales.
The age-standardized death rate in England in September due to COVID-19 was 12.6 per 100,000 people.
It was 10.8 per 100,000 people in Wales.
The rate is a weighted average of age-specific death rates per 100,000 people.
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Pfizer vaccine: 20 million doses already produced
Although death rates from COVID-19 have increased in October 2020, they are still significantly lower than in April and May 2020.
The leading cause of death in October was dementia and Alzheimer’s disease, accounting for 11.3% of all deaths in England and 10.2% in Wales.
The second most common cause of death in October was heart disease.
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So far, there have been 448,579 deaths overall in England in 2020, 37,873 more than the five-year average from January to October, according to the ONS.
There have been 29,018 deaths in Wales, 1,419 more than the five-year average.
COVID-19 was the underlying cause of 50,012 deaths that occurred in England (11.1%) and 2,629 of all deaths in Wales (9.1%) from January to October 2020.
The University of Oxford has said its COVID-19 vaccine produces a strong immune response in older adults.
The results from phase one and phase two suggest that one of the groups most at risk of death or serious illness from COVID-19 could develop immunity, according to data published in the medical journal The Lancet.
