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Labor leader Sir Keir Starmer isolates himself after a member of his family “showed possible symptoms of the coronavirus,” the party said.
The person showing symptoms has had a test and Sir Keir is now awaiting the results “in line with NHS guidelines,” they added.
The Labor leader will not speak in Monday’s Commons debate on the government’s post-Brexit plans.
However, he is not reported to have shown any symptoms of coronavirus.
Sir Keir, who will address the TUC Congress on Tuesday, learned of the concerns about his household member after an appearance on LBC radio Monday morning.
Last week, Commons Leader Jacob Rees-Mogg announced that he was self-isolating at home after one of his children showed symptoms of coronavirus.
The infection rate is increasing across the UK, and rules restricting the size of social gatherings go into effect in England, Scotland and Wales from Monday.
A Labor spokesman said: “This morning Keir Starmer was advised to isolate himself after a member of his household showed possible symptoms of the coronavirus.
“Your household member has undergone a test. In accordance with NHS guidelines, Keir will isolate himself while he awaits the test results and further advice from medical professionals.”
The move comes ahead of what would be one of Sir Keir’s biggest parliamentary performances since he became Labor leader in April.
Instead, the shadow business secretary and former leader Ed Miliband will open the debate on the government’s internal market bill for the party on Monday afternoon.
The legislation attempts to nullify parts of the Brexit withdrawal agreement reached by the UK and the EU.
Prime Minister Boris Johnson was taken to intensive care in April after contracting the coronavirus.