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Mouthwash can eradicate the coronavirus within 30 seconds of being exposed to it in a laboratory, according to a scientific study.
The preliminary result comes ahead of a clinical trial on whether the use of over-the-counter mouthwashes has the potential to reduce Covid-19 levels in a patient’s saliva.
The Cardiff University report said that mouthwashes containing at least 0.07% cetypyridinium chloride (CPC) showed “promising signs” of being able to fight the virus.
The report, The Virucidal Efficacy of Mouthwash Components Against SARS-CoV-2 In Vitro, has yet to be peer-reviewed, but supports another study published last week that found CPC-based mouthwashes to be effective in reducing Covid viral load.
The latest test was performed by scientists in the university lab and mimicked a person’s naso / oropharyngeal passage conditions using mouthwash brands like Dentyl.
Next, a clinical trial will examine how effective mouthwash is in reducing the viral load in the saliva of Covid-19 patients at the University Hospital of Wales in Cardiff, and its results will be published in the early part of 2021.
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Dentyl is the only UK mouthwash brand to participate in the 12-week clinical trial, led by Professor David Thomas of Cardiff University and entitled: “Measuring the antiviral activity of mouthwash against Covid-19” .
Dr. Thomas told the Palestinian Authority news agency: “While these mouthwashes eradicate the virus very effectively in the laboratory, we need to see if they work in patients and this is the goal of our clinical study in course.
“It is important to note that the study will not give us any direct evidence on viral transmission between patients, which would require a different type of study on a much larger scale.
“However, the ongoing clinical study will show us how long the effects last after a single administration of the mouthwash in patients with Covid-19.”
He added: “Although this in vitro study is very encouraging and a positive step, more clinical research is now needed.
“We need to understand whether the effect of OTC mouthwashes on the Covid-19 virus achieved in the laboratory can be replicated in patients, and we hope to complete our clinical trial in early 2021.”
Dr Nick Claydon, a specialist periodontologist, said he believed the research was “very valuable.”
He said: “If these positive results are reflected in the Cardiff University clinical trial, CPC-based mouthwashes like the Dentyl used in the in vitro study could become an important addition to people’s routine, along with with hand washing, physical distancing and the use of masks. ” both now and in the future. “
Dr Richard Stanton, lead author of the study and a virology reader at Cardiff University, said: “It is remarkable that coronaviruses are much more susceptible to alteration than many other viruses and bacteria due to the presence of a viral lipid envelope. Studies to see if the approach can inactivate the virus in humans are ongoing.
“In the human throat the virus is constantly being produced, so if there is an effect it will be important to see how long it lasts and if this could help reduce transmission, for example in dental investigations, mouth / throat exams performed by GPs., or short-term contacts with vulnerable patients or others.
“People should continue to follow UK government issued preventive measures, including frequent hand washing and social distancing. We encourage people to always use mouthwashes safely and according to manufacturer’s guidelines.”
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