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A further 28 coronavirus-related deaths have been reported in Midlands hospitals, as UK numbers jumped by 218.
There were a total of 185 deaths recorded in England, while Wales suffered 16, Scotland reported 11 and Northern Ireland had six.
The numbers cover people who have tested positive for coronavirus in the past 28 days.
The latest victims in England were between the ages of 32 and 98, with 78 deaths also reported in the North West and a further 48 deaths in the North East and Yorkshire.
Weekly statistics from the partially privatized NHS Test and Trace system show 101,494 people tested positive at least once a week through October 14.
This is a 12 percent increase from the previous week and is the highest since the launch of Test and Trace in late May.
Another 1,324 people have tested positive for coronavirus in Wales, bringing the total number of confirmed cases to 41,577.
The total number of deaths during the pandemic in the principality amounted to 1,772.
The NHS will not be able to cope if coronavirus cases continue to rise at the current rate, a scientist warned.
Professor Neil Ferguson, whose model led to the original shutdown in March, said that while infections among 18-21-year-olds were declining, they were still increasing in other age groups.
“Unfortunately, in all other age groups, the number of cases continues to increase at about the same rate that it was. There are small signs of a slowdown.
“It is a worrying situation. We now have 8,000 people in the hospital with Covid. That’s about a third of the level we were at the peak of the pandemic in March.
“If the growth rate continues as it is, it means that within a month we will exceed that maximum level in March and that is probably unsustainable.
“We are at a critical moment right now. The health system will not be able to cope with this growth rate for much longer. “
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