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In a study coordinated by the World Health Organization (WHO), it was announced that three steroids – hydrocortisone, methylprednisolone and dexamethasone) reduced the risk of death by 20 percent in new types of critically ill coronaviruses.
1,703 CRITICAL PATIENTS WERE EXAMINED IN 12 COUNTRIES
In the joint research article by the WHO and the National Institute for Health Studies at the University of Bristol published in the Journal of the American Medical Association (JAMA), 7 studies on the use of 3 different steroids in patients were evaluated with Kovid-19 in 12 countries. In seven control trials, 1,703 critically ill corona patients were followed for 28 days from February to June.
THE COMMON USE OF HYDROCORTISONE IS RECOMMENDED AFTER DEXAMETASONE
Hydrocortisone, a drug commonly used to treat allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, multiple sclerosis, or lung problems, has been announced to reduce the risk of death in Kovid-19 patients by up to 31 percent. hundred.
The scientists’ announcement makes hydrocortisone the second most commonly recommended steroid for Kovid-19, after dexamethoose.
The efficacy of dexamethasone has been previously tested by the University of Oxford, and the WHO has announced that it can reduce deaths from Kovid-19 by 60 percent.
CONSISTENT RESULTS
Jonathan Sterne, Professor of Medical Statistics and Epidemiology at the University of Bristol, said in a statement on the matter. “Steroids are inexpensive and readily available drugs, and our analysis confirmed that they were effective in reducing deaths among those most severely affected by Covid-19. The results were consistent across all trials and benefited regardless of age or gender. “. used expressions. However, Sterne’s findings “Eight fewer deaths for every 100 critically ill patients” stated that he was pointing.
87 LESS DEATHS IN EVERY THOUSAND PATIENTS
The WHO clinical care specialist, Janet Díaz, on the other hand, drew attention to the importance of the use of steroids in critical patients with COVID-19, “There is evidence of 87 fewer deaths per 1000 patients who received corticosteroids. This saves lives.” used expressions.
STEROIDS PREVENT CYTOKINE STORIES
Scientists say that dexamethasone, hydrocortisone, and methylprednisolone prevent cytokine storms that occur as a result of the body’s immune response. Most Kovid-19 patients die from the excessive immune response elicited by the corona, which attacks the body’s own cells.
WHAT IS A CYTOKINE STORM?
Destructive lung inflammation triggered by a cytokine storm is considered the most important factor in the death of corona patients.
A group of cells involved in the immune system’s response to injury or infection is called cytokines. The Stokins compete to get to where the problem arises, signaling that more immune cells be dispatched to defend the body from a foreign invader.
Cytokines, which play an important role in the body’s self-healing, can cause devastating damage after a while. When the flow of immune cells is permanent, inflammation occurs, which begins to destroy the cells of the tissues that the immune system tries to protect.
Inflammation can be out of control for a long time due to excessive cell signaling of cytokines. This inflammation causes respiratory failure by filling the lungs of patients with viruses. If inflammation cannot be controlled, many patients die.
SOURCE: NTV
