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Professor of Molecular Biology and Genetics at Boğaziçi University. Dr. Nesrin Özören stated that new types of coronavirus vaccine studies (Covid-19) are underway.
Covid-19 vaccination professor with his team Dr. Nesrin Özören said: “At the end of the second month, we did what we had planned in a month. We are starting animal and cell experiments soon. We want to start animal experiments in early June. At best, we will reach Phase 3 in September 2021, where the vaccination candidate is ready. “
Özören said that under the coordination of the Ministry of Industry and Technology, TÜBİTAK coordinated 7 groups for new types of coronavirus vaccination studies, independent projects will work on common materials and transgenic animal studies, and testing of the vaccine candidate virus It will take place in one of the centers with third level biosafety laboratories.
Recalling that the “fast, product-oriented” 12-month project of the Department of Molecular Biology and Genetics at Boğaziçi University, of which he was director, was approved in late March, Özören continued:
“Our technology is proprietary technology that is based on protein microspheres. We have worked on this before for the avian influenza protein, now we target the regions of the corona protein. If we think of it as a ready-made production band, now we have adapted our strategy to the corona virus. It was our first month of April, the first report of the month We gave it at the beginning of May. Our project is going well. At the end of the second month, we did what we had planned in one month. starting animal and cell experiments soon. I can say we went a month before our previous plan. We want to start animal experiments in early June. “
Özören gave the following information by indicating whether there was an immune response to the virus fragments administered in animal experiments, and then testing the dose of the administered vaccine preparation:
“It can usually take 6 months. We will try to finish in no time, like 1 or 2 months. Phase 1 study to set up a team on track for job readiness and need to present it. Turkey Pharmaceuticals and ready for regulations from the Medical Devices Agency. We have them on an accelerated basis CORONA in we plan to practice against.
Regarding my project, we would like to prepare our phase 1 file to start next January. Whether the sample of vaccine administered to 10-15 people in Phase-1 is harmful or not, the number of doses is controlled. If phase 1 is successful, you will go to phase 2 to work with 100-200 people. In the Phase 2 study, the health status, blood values, and biochemical values of people who received the vaccine are examined. When vaccinated, they should be followed. They stay in the hospital for a certain period of time or go to the hospital to take routine samples. If this process takes 2 to 3 months, we can think that the vaccine candidate is ready in phase 3. If we say phase studies for at least 6 months, in the best case we will reach phase 3 in September 2021 “.
Mentioning that it takes 5 to 6 years to develop a completely new vaccine, Özören said: “While the Corona virus kills so many people, we have to do some things in a shorter way. In other countries, there are vaccines and they are going through these forms.At critical times, a short form may be preferred.Combining phase 1 and phase 2, 2 months are obtained, and phase 3 and phase 4 are carried out together. 2-3 months are obtained, and if all team works in a coordinated way, it takes a long time.
” 80-90 PERCENT WILL WORK ”
Özören, “The protein microsphere technology at Boğaziçi University belongs to us and we have seen that it has been successful in animal experiments before. I think our hand is very strong in this regard. I am 80-90 percent sure that it will work. We can treat many things in the mouse, but when we go to humans, for example 1000 people in laboratory conditions because we do not have the capacity to produce vaccines. There are parts that must be done in bioreactors. January after phase 1 and phase 2 and Phase 3 and the capacity contained in the bioreactor in Turkey for the readiness study should be given to the people we need to collaborate with private companies, ” he said.
“EACH MUTATION DOES NOT AFFECT THE VIRUS STRUCTURE”
Professor Dr. Nesrin Özören stated that companies conducting SARS and MERS studies in Germany and England are prepared for vaccination studies against the coronavirus and carried out the following evaluations:
“Now only additional experiments will be done for the crown. I suppose a set of vaccines like September-October will be ready to be produced or administered to people. Naturally, countries will produce vaccines for their own citizens. It is not very easy to produce vaccines for the entire world population. They are mainly transported by the cold chain. ” expected in conventional technology. However, Boğaziçi University in systems where we develop microsphere vaccines at room temperature can be transported without distortion. Other similar projects in Turkey with the world. “
Noting that the virus has not undergone a major structural change, Özören said: “Not all mutations have an effect on the structure of the virus. The mutation that will change the structure that we have observed has not yet changed. It is not such a terrible virus It is deadly like Ebola and elusive like now, for 14 days. ” If a person could stay and spread without symptoms, then it would have been necessary to panic. “
“A LARGE PART OF THE GROUPS THAT WORK WITH VACCINE WORKS ARE MOLECULAR BIOLOGIES”
Professor of Molecular Biology and Genetics at Boğaziçi University. Dr. Nesrin Özören, vaccine production centers in Turkey, said it was later discarded when it was launched and then sealed in the 1980s: “I hope that the Corona virus, which is valuable, is an opportunity to evaluate the profession. The proportion of national R&D income spends 1 percent more, but that The research areas are not basic sciences, but optimization, engineering Investing in science and research will not be like that.
Biologists from the Coronavirus Science Board are carried out by pointing out Özören “However, vaccine development does occur in those groups of most molecular biologists. Paving the way for molecular biologists If science wants to produce, not the experts at The basic sciences among the top decision makers establish important.If they had not done Turkey, the professionals cannot go beyond being, ” he said.
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