There are more than 130 possible coronavirus (COVID-19) vaccines that researchers around the world are currently working on. Of them, 19 are being tested on humans.
After some encouraging initial results, the researchers remain cautiously optimistic that a safe and effective vaccine can be made. Some of the biggest questions will be answered in the coming weeks as large-scale human trials are conducted around the world.
Around 8,000 people in the UK have received the vaccine developed by the University of Oxford.
Phase three trials are also being carried out in Brazil, where 4,000 people will be vaccinated, and in South Africa, where 2,000 volunteers began lining up for the vaccine.
Oxford was already working on a vaccine for a different coronavirus when the pandemic occurred, giving researchers an advantage in testing it.
“This is the first study to be conducted on the African continent, but in all likelihood it will be the first of at least three to four other COVID-19 vaccine studies – different vaccines,” said Shabir Madhi, professor. of vaccinology at Wits University.
In the UK, volunteers are also testing a vaccine developed by Imperial College London. This stage will include 300 people with a trial of 6,000 people planned for October.
In the United States, the vaccine created by the biotech company Moderna is entering phase three trials with plans to test it on at least 1,000 people in Chicago, starting this month.
At least 4,000 participants will be over 65 years old. The researchers also want to include many African American and Hispanic volunteers.
“I don’t think it’s that difficult to find interested people,” said Dr. Richard Novak, chief of infectious diseases at the University of Illinois at Chicago.
Pfizer and its German biotech partner Biontech have just announced the results of the phase one and two trials. The 24 volunteers who received two doses of the vaccine developed higher levels of antibodies than those typically seen in recovered patients.
More than half reported non-serious side effects, such as fever and sleep disruption.
“After the second dose, I felt a little pain and my temperature was elevated, so I took a Tylonol and felt better,” said one patient.
Researchers in Australia, India, and Europe are also testing a tuberculosis vaccine developed in the early 1900s to see if it could offer any partial protection against COVID-19.
The groups being tested at this time do not include pregnant women and children, but obviously the researchers will also need to make sure that the vaccine is safe for them.
Once a vaccine is proven to be safe and effective in the initial study participants, the researchers will go back and redo the early stages of the trials and will include pregnant women, children, and people with more health problems. It will be tested on volunteers from those groups before it becomes widely available.
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