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The first experiences with the remdesivir agent originally developed for Ebola give us confidence. Reliable results from large international studies are still pending.
Remdesivir has been a promising candidate for Covid-19 treatment for several weeks. In a study by the University of Chicago Clinic, the drug, originally developed against Ebola, led to a rapid reduction in fever and a reduction in symptoms of lung disease.
After less than a week of drug therapy, nearly all patients were discharged, according to a report released Thursday afternoon by online medical news platform “Stat.” The company’s shares rose 16 percent after the US market closed.
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The drug’s maker, Gilead, said the data had to be analyzed to draw conclusions. The university clinic in Chicago indicated in an email that partial data from an ongoing study should not be used to obtain results. The contents of an internal forum for scientists were recorded and published without permission.
Kathleen Mullane, an infectious disease expert at the University of Chicago, made it clear to “Stat” that she shouldn’t read the information too much.
The pharmaceutical company expects to be able to announce the first results of the ongoing phase 3 study by the end of the month. Chicago University Hospital is one of 152 hospitals participating in the Gilead study of severely ill Covid 19 patients.
According to the “Stat” news platform, 125 people were treated in Chicago as part of the study. Of the patients included in the analysis, 113 had a severe course of the disease. They treated you with daily infusions of Remdesivir.
According to pharmaceutical manufacturer Gilead, the drug is currently being tested in six studies worldwide, including in Switzerland, for the treatment of patients with Covid 19.
Study with individual healing attempts.
If approved therapies are not available for a patient, physicians may use an active ingredient without authorization under certain conditions (compassionate use). In an April 10 publication in the “New England Journal of Medicine,” such individual healing attempts with remdesivir were reported, which were carried out with a small group of patients at Cedars-Sinai Medical Center in Los Angeles, USA. ).
Of the 53, mostly male patients, 34 had to be mechanically ventilated. A third of the test subjects had already reached the age of 70. 36 of the treated patients showed an improvement on average 18 days after the first infusion with Remdesivir. Eight patients worsened their health. Seven of them died.
These data should also be used with caution. Only a small group of patients was observed. Furthermore, there was no control group of study participants for comparison who were not treated with remdesivir, but only with standard therapy.
Whether or not Remdesivir receives approval for Covid-19 treatment depends on the results of ongoing clinical trials.
The coronavirus crisis: a timeline
The coronavirus crisis: a timeline
December 1, 2019 – A patient who will later prove to be the first documented case of nCov 2019 is examined by doctors in Wuhan, China.
January 2, 2020: 41 of the hospitalized patients in Wuhan, China are confirmed to have the 2019 nCoV. 27 patients were directly exposed to the Huanan wholesale seafood market.
January 9: The World Health Organization confirms that the new coronavirus has been successfully isolated by one person.
January 16: The number of diseases caused by the new corona virus in China has increased to more than 1,600. 142 people died across the country from the consequences of the disease, according to the NHC national health commission.
January 20: Sudden rise in new lung disease: The disease has spread outside of China for the first time. Three people have already died from that. South Korea also reports the first case.
January 31: Ten Swiss want to leave China. The BAG provides information on the “logistically challenging” return flight made by the Swiss from Wuhan.
February 5: The “Princess Diamond” is anchored in Yokohama. There are also two Swiss on the cruise, which is quarantined in the port of the Japanese city of Yokohama. There are at least ten confirmed cases on board.
February 7: Dr. Li Wenliang dies. He was known because he had apparently already warned on December 30 about the new variant coronavirus (SARS return).
February 19: Iran confirms the first two deaths.
February 21: Italy confirms 17 cases, bringing the total number of infected people to 20. Authorities also report the first death, a 78-year-old man dies from Covid-19.
February 25: “It was only a matter of time, now is the time”: a 70-year-old man from Ticino has tested positive for the new corona virus, according to authorities.
February 25: Outbreak in several cities in northern Italy. The police cordon off Cinto Euganeo near Padua.
February 27: According to the authorities, the first infection with the corona virus was confirmed in the canton of Zurich. A 30-year-old man who was in Milan until a week earlier is affected.
February 28: Switzerland cancels flights to Italy: connections to Venice, Florence, Milan and Rome are affected. “Due to the change in the reserve situation due to the effects of the corona virus, Swiss and the Lufthansa Group decided to reduce frequencies to Italy by the end of March 2020,” the company said.
February 28: Federal Council bans all major events: Due to the rampant crown virus, the Federal Council bans all major public events with more than 1,000 participants. According to the Interior Department, the ban is valid until March 15 and was imposed due to the special situation.
February 29: First Covid death 19 in the United States. United States Vice President Mike Pence leads the crisis team there.
March 1: Federal Council session begins with some restrictions. National Council President Isabelle Moret (FDP / VD, right) prohibits Council members, including Magdalena Martullo-Blocher (SVP / GR, left), from wearing masks.
March 5: The first coronavirus death in Switzerland: a 74-year-old woman dies and was treated at the University Hospital of Lausanne. She suffered from a chronic illness.
March 8: Italy takes unprecedented steps to curb the spread of the virus. In the north of the country, a basic entry and exit ban applies until April. Milan’s economic metropolises are also affected (in the photo, the city’s main train station).
March 9: Stock markets are declining worldwide; Trade in New York has even been suspended. There are losses in the billions.
March 11: The World Health Organization (WHO) has classified the spread of the coronavirus as a pandemic. Given the worldwide spread of the pathogen, he was “deeply concerned” about the “alarming level of inactivity” in the fight against the virus, WHO chief Tedros Adhanom Ghebreyesus said in Geneva.
March 13: UEFA has suspended matches in the Champions League and Europa League due to the coronavirus crisis. All matches for next week have been canceled, UEFA announced.
March 13: The Federal Council significantly tightened measures in the fight against the coronavirus. Events with more than 100 participants are now banned, and face-to-face classes at all schools will be suspended until early April.
March 15: Germany closes its borders to several neighboring countries, including Switzerland.
March 15: Federal councils cancel their spring session in light of the rapid spread of the virus.
March 16: The Federal Council classifies the situation in Switzerland as an “exceptional situation”: this is the highest of the three possible levels.
As of March 17 at midnight, Switzerland is practically in a state of emergency. All shops, restaurants, bars, leisure and entertainment facilities will be closed until April 19. Except for health facilities and grocery stores. All public and private events are prohibited.
At the Swiss borders with Germany, Austria and France there have been controls again since March 17. At the borders with Italy, such were already introduced on Friday, March 13.
March 17: The EU also closes the external border. Specifically, all travel between non-European countries and EU countries is suspended for 30 days.
March 18: The Federal Council decides that the debtors can no longer be operated in Switzerland before April 4. The state government has ordered this so-called “legal suspension” to ease companies, as Federal Council spokesman André Simonazzi said.
March 18: Voting on the immigration initiative was postponed due to the coronavirus pandemic. The Federal Council decided not to hold the federal referendums scheduled for May 17. (Icon Image)
March 19: In the canton of Uri, people over 65 are not allowed to leave their house or apartment at night, with some exceptions. Cantonal administration staff will issue an exit restriction for them starting at 6 p.m. (Icon Image)
March 19: Italy has reported more deaths in the coronavirus pandemic than China, making it the country with the highest number of officially reported deaths in the world. So far, 3,405 people have died, the Italian civil defense said Thursday in Rome. The number of deaths in Italy increased by 427 in one day.
March 20: In public spaces, for example on the street, lakeside or in parks, any gathering of people of more than five people is now prohibited. Failure to comply with this rule will result in a fine.
March 20: The number of coronavirus diseases in Switzerland continues to rise rapidly: on Friday afternoon there were 4,840 confirmed cases, 952 more than 24 hours earlier, as announced by the Federal Office of Public Health (BAG). So far, 43 people have died from Covid-19 infection. (Icon Image)
March 21: Italy experiences the worst day of the pandemic so far: almost 800 people die in 24 hours.
March 22: German Chancellor Angela Merkel must be quarantined in the Corona crisis. She was in contact with an infected doctor.
March 22: Every six minutes in Madrid, a person infected with coronavirus is brought dead from the hospital room. The intensive care units in the Spanish capital are now overcrowded, the staff is totally overwhelmed.
March 23: More than 15,000 deaths and increasingly stringent exit restrictions for around 1.7 billion people worldwide: A sense of panic is spreading worldwide in the face of the coronavirus pandemic. Therefore, more than 50 countries and areas restrict the freedom of movement of their citizens.
March 23: In March, 21,000 companies applied for short-term jobs for 315,000 employees. The Swiss leading SMI index fell 5.37 percent on Monday to 8,160.79 points.
March 24: The Tokyo Olympics are postponed until 2021 due to the crown pandemic. The International Olympic Committee and the Japanese hosts agreed on Tuesday, the IOC said.
March 25: Spain is the second country in Europe to report 3,434 more deaths than those recorded in China. The United States Senate approved a billion-dollar economic stimulus package to mitigate the economic consequences of the crisis.
March 29: More than 140,000 more infections are now known in the US USA That officially registered in any other country in the world. According to Johns Hopkins University, the number of records in Germany exceeds 60,000, and there are more than 540 deaths.
March 30: According to the Federal Office of Public Health BAG, 15,475 crown cases have been confirmed in Switzerland. A total of 295 people have died as a result of Covid-19.
April 1: In the United States, the 200,000 person limit was exceeded. The situation in New York State is particularly bad. The increasing number of cases worldwide also warned the WHO, where they were concerned about the “rapid escalation” of the situation.
April 4: To curb the Corona crisis, the Spanish government plans to extend the state of emergency and the strict curfew across the country for another two weeks until April 26. Prime Minister Pedro Sánchez said.
April 5: In a television address, Queen Elizabeth II called on her people to persevere and be disciplined in the coronavirus pandemic. Aside from the Christmas speeches, it was just the Queen’s fourth speech, which had been in office since 1952.
April 6: Austria wants to take a step towards normality after Easter. Chancellor Sebastian Kurz announced that starting April 14, small stores as well as DIY megastores with garden centers can reopen under strict conditions.
April 7: British Prime Minister Boris Johnson is being treated in the intensive care unit of a London hospital for his Covid disease 19.
April 8: In Switzerland, measures against the pandemic extend for a week and now last until April 26. The Federal Council (pictured: Federal President Simonetta Sommaruga, Health Minister Alain Berset) offers the possibility of an initial relaxation for the subsequent period.
April 9: The number of Sars-CoV-2 cases detected worldwide has exceeded the 1.5 million mark. The International Monetary Fund (IMF) expects the worst economic impact since the Great Depression of 1929 due to the coronavirus pandemic.
April 12: British Prime Minister Boris Johnson has been released from the hospital. “Today I was released from the hospital after a week,” he said in a video message posted on Twitter. The state health service NHS (National Health Service) saved his life.
April 14: Austria takes the first step to normality. Smaller stores and hardware stores may reopen, but customers should wear mouth and nose protection.
April 15: The President of the United States, Donald Trump, stops paying contributions to the World Health Organization (WHO) and accuses him of “mismanagement and cover-up.”
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