Researchers have identified a process that causes aging of the skin and other human organs, which could prove to be a major breakthrough in the field of regenerative medicine.
By “Cellular Reprogramming,” A team from the University of Wisconsin-Madison has discovered a mechanism that regulates the aging and rejuvenation of mesenchymal stem cells (MSc), which can vary in different cell types, such as muscle or bone.
Their study, published in the journal Stem Cells on Monday, adds that scientists already knew how cellular processes cause MSc to age.
“Our study provides an insight into how regroup program MSc is molecularly regulated to enhance the cellular hallmark of aging.” Said its co-authors One-Ju Lee.
“We believe our findings will help us understand the importance of MSc in aging and regenerative medicine.”
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Regenerative therapy is concerned with regenerating, replacing and healing organs or tissue damage by age and disease.
Researchers derived MSc from human synovial fluid, the body’s natural lubricant, found around the joints, including the knees and elbows. By then transforming the MSC into a fetal-like state in the form of a ‘regenerated’ stem cell, scientists offer scientists the possibility to form any cell in the adult body.
The team found that protein (GATA6) was suppressed in altered MSC cells, leading to an increase in another protein (known as SHH) and the expression of another (called Foxp1), which is active in brain development, heart and lungs. .
Editor of Stem Cells Jan. Jan Nolta holds an M.Sc. No one applauded the identification of this protein pathway to control aging. “A very important achievement.”
Researchers at Tel Aviv University in Israel have made the discovery following a recent separate study that claimed to reverse the world’s first cellular aging process.
But compared to the Wisconsin-Madison University study, the Israeli study is more controversial because of the process used to shorten those telomeres – small tips at the end of each chromosome. Later in life, this process increases the risk of age-related diseases, including heart disease, diabetes and cancer.
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