WHO Positioning on Vaccination of BCG and COVID-19

There is no evidence that the Bacille Calmette-Guérin (BCG) vaccine protects people against infection with COVID-19 viral hair. Two clinical trials that address this question are at the WHO and will support the evidence when you have it. In the absence of evidence, WHO does not recommend vaccinação com BCG for the prevention of COVID-19. The WHO continues to recommend a neonatal vaccination against BCG in countries or countries with a high incidence of tuberculosis. ^eleven

There are evidence of animal and human studies that BCG vaccinates fear non-specific effects, not an immunological system. These effects are not characterized by their clinical relevance and are unknown. ^2.3

On April 11, 2020, the WHO updated its review of evidence in two major scientific data banks and repositories of clinical trials, using search terms in English, French and Chinese for COVID-19, coronavirus, SARS-CoV-2 e BCG.

A review produced three pré-impressões (manuscripts published online before peer review), we authors compared the incidence of COVID-19 cases in countries where BCG vaccine was used and countries where it was not used and we observed that The countries that use rotineiravacina in vacina. Vacina in neonates tinha less reported cases of COVID-19 até or moment. Such ecological studies are prone to significant numbers of very confusing symptoms, including differences in national demographics and burden of diseases, taxa for testing for COVID-19 virus infections and the outbreak of pandemic in each country.

A review also produced two protocols registered for clinical trials, both as the objective of studying the effects of BCG vaccination administered to health professionals directly involved in non-care of patients with COVID-19. ^4.5

A BCG vaccination prevents severe forms of tuberculosis in children and the deviation of local suppressions can result in the vaccination of two newborns, resulting in an increase in deaths and deaths from tuberculosis. ^6-8 In the absence of evidence, WHO does not recommend vaccinação com BCG for the prevention of COVID-19. The WHO continues to recommend a neonatal vaccination against BCG in countries or countries with a high incidence of tuberculosis.

References

1. BCG Vaccines: document of the WHO position – February 2018. BCG Vaccines: Note from WHO, Fevereiro 2018. Wkly Epidemiol Rec. 2018; 93 (8): 73–96. Published 2018 Feb 23.
2. de Bree LCJ, Marijnissen RJ, Kel JM, et al. A trecinated immunity induced by Bacillus Calmette-Guérin is not protective for experimental infection with influenza A / Anhui / 1/2013 (H7N9) in rats [a correção publicada aparece no Front Immunol. 25 de outubro de 2018; 9: 2471]. Front Immunol. 2018; 9: 869. Published em April 30, 2018. doi: 10.3389 / fimmu.2018.00869.
3. Arts RJW, Moorlag SJCFM, Novakovic B e outros. A vaccination with BCG protects against viral infections you experience in humans through the induction of cytokines associated with treminated immunity. Cellular host microbe. 2018; 23 (1): 89–100.e5. doi: 10.1016 / j.chom.2017.12.010.
4. Reduction of absenteeism by two workers from the health area in the Covid-19 pandemic through the BCG vaccine (BCG-CORONA). https://clinicaltrials.gov/ct2/show/NCT04328441.
5. Vacinação BCG to protect you profissionais de saúde against o COVID-19 (BRACE). https://clinicaltrials.gov/ct2/show/NCT04327206.
6. Cernuschi T, Malvolti S, Nickel E, Friede M. Bacillus Calmette-Guérin (BCG): A global assessment of demand and balance of supply. Vacina. 2018 janeiro 25; 36 (4): 498–506. doi: 10.1016 / j.vaccine.2017.12.010
7. Du Preez K, Seddon JA, Schaaf HS, Hesseling AC, Starke JR, Osman M, Lombard CJ, Solomons R. Global scarcity of BCG vaccine and meningite tuberculosa em crianças. Lancet Glob Health. 2019 jan; 7 (1): e28-e29. doi: 10.1016 / S2214-109X (18) 30474-1.
8. Roy P, Vekemans J, Clark A, Sanderson C, Harris RC, White RG. Potential effect of BCG vaccination with global mortality due to pediatric tuberculosis: a modeling study. Lancet Glob Health. 2019 ten; 7 (12): e1655-e1663. doi: 10.1016 / S2214-109X (19) 30444-9

* With information from WHO

Text by Fábio Reis for PFARMA

* A reproduction is allowed since the aforementioned fonte com link for https://pfarma.com.br

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