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CThese antibodies may be causing severe and prolonged levels of COVID-19-19. The findings of a team of researchers from Yale University in the United States may be important in the search for an effective drug for the disease. Please note that the study has not yet been published in any scientific journal and has not yet been peer reviewed.
According to The Guardian, researchers found a large number of stubborn antibodies in patients infected like new coronavirus. Instead of fighting the virus, they compromised the system immune patients. the autoantibodies can explain the different reactions to infection skin SARS–CoV-2.
To reach this conclusion, the immune response in patients infected and people don’t infected was compared. U.S infected, dozens of rogue antibodies blocked defenses antiviral, killed helpful immune cells and attacked the body on several fronts, from the brain, blood vessels, and gastrointestinal tract. According to scientists, this is because certain antibodies have the form incorrect and connect wrongly to proteins that are present or have been released by human cells. How many more autoantibodies the patients had blood, the worse the disease.
“We believe that these autoantibodies are harmful to patients with COVID-19-19 “, said the immunobiologist Yale and author of the study by Aaron Ring. Harmful effects may continue after infection, leaving patients with longer lasting problems.
Aaron Ring e Akiko Iwasaki, teacher immunobiology at Yale, examined 194 patients and hospital staff of varying severity infection by COVID-19-19 looking for autoantibodies managed to nearly 3,000 human proteins. More than 5% of hospitalized patients had autoantibodies which weakened proteins called interferons, that help Activate the immune system for a infection. These patients were unable to control the amount of virus in their bodies and developed more serious illnesses.
In two other examples, patients autoantibodies managed to B cells, the cell factories that make antibodies to fight the virus, while a patient autoantibodies which seemed to kill a lot of your T cells protective.
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