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Real Madrid suffered a shocking 1-0 home defeat to the promoted Cádiz, while Barcelona was beaten by the same score at Getafe, which moved to second place in LaLiga.
Real Madrid coach Zinedine Zidane offered no excuses when the reigning champions fell in a first loss to Cádiz.
Anthony Lozano’s goal in the first half was enough for an unlikely victory for the newcomers, who held off an attack in the second half at the Alfredo Di Stefano Stadium with a late effort from Karim Benzema hitting the crossbar.
Barcelona, however, could not capitalize as a penalty from Jaime Mata after 56 minutes settled the matter at the Alfonso Pérez Coliseum.
Lionel Messi had hit a post during the first half, but it was a frustrating evening for the Catalans as Getafe, who also crashed into wood in the closing stages, tied on points with leaders Madrid.
Barça’s first defeat of the season to head coach Ronald Koeman leaves them ninth in the table, three points behind, but still one game short.
Luis Suárez’s early goal put Atlético de Madrid on track to a 2-0 win at Celta de Vigo, with substitute Yannick Carrasco adding a second in injury time.
Granada beat Sevilla 1-0 on a late goal from Yangel Herrera after the visitors saw midfielder Joan Jordan Moreno sent off shortly before half-time.
Zlatan Ibrahimovic scored two goals in the first half, one from a rebound from a saved penalty, when Serie A leaders AC Milan beat Inter 2-1 to win the Derby della Madonnina.
Ibrahimovic, back in shape after a positive Covid-19 test, put the Rossoneri ahead after 13 minutes when he went home on the second attempt after Samir Handanovic had rejected his shot from the point.
Soon it was 2-0 after a quick counterattack, Ibrahimovic conceded a cross from the left by Rafael Leao.
Inter got a goal from Romelu Lukaku in the 29th minute, but it was AC Milan who took the spoils to maintain their perfect start.
Champions Juventus – without self-isolating Cristiano Ronaldo – beat a 1-1 draw at Crotone, where Federico Chiesa saw a red card on his debut for the visitors.
Simy put the hosts ahead from the penalty spot, but midfielder Chiesa, a transfer from Fiorentina at the deadline, set Álvaro Morata ready for a draw in the 21st minute.
Juve were left with 10 men in the hour following the direct red card to Chiesa for a foul on Luca Cigarini, but thought they had won it when Morata scored in the 76th minute, only for the VAR to annul the goal for a time . marginal offside.
Napoli is second after a 4-1 win over Atalanta, with Hirving Lozano scoring a double in the first half. Sampdoria are sixth after beating Lazio 3-0.
RB Leipzig held onto a point lead at the top of the Bundesliga with a 2-0 win over Bavarian rival Augsburg.
Defender Angelino headed the visitors ahead on the edge of the break, and substitute Yussuf Poulsen volleyed in a second shortly after going in in the 66th minute.
Bayern Munich beat Arminia Bielefeld 4-1, where Thomas Muller and Robert Lewandowski scored twice and midfielder Corentin Tolisso was sent off at the end.
Visitors had to use the changing rooms at a nearby school before the game due to strict Covid-19 regulations.
Borussia Dortmund also have nine points from four games after a late goal from Marco Reus secured a 1-0 win at Hoffenheim.
Stuttgart beat Hertha Berlin 2-0 to take fourth place, while Mainz lost 1-0 at home to Bayer Leverkusen.
In the last game on Saturday, Wolfsburg drew 1-1 against Borussia Monchengladbach with a late goal from Wout Weghorst, while they also drew 1-1 between Freiburg and Werder Bremen.
In France, Marseille beat Bordeaux 3-1 to record their first Ligue 1 victory in five games.
Florian Thauvin put the hosts into an early lead after just five minutes, with Jordan Amavi also on target in the second half.
An own goal from Pablo closed things out before a belated consolation from Bordeaux substitute Josh Maja.
Earlier, Lorient came back to win 3-1 at Reims, which had midfielder Moreto Cassama and substitute Anastasios Donis sent off during the later stages.
