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Coronavirus, three proposals from Rome for the most anticipated vaccine on the planet. Three companies in the pharmaceutical center of Pomezia and Castel Romano, at the gates of the capital, are in the running, experimentation has already begun. Advertisements are chased every day and confuse ideas, but today the situation is this: Irbm, based in Pomezia, is collaborating with the Jenner Institute of the University of Oxford, where human experimentation, in a group of volunteers, has already begun. British Economic Development Minister Anne-Marie Trevelyan explained, illustrating some plans to find the vaccine: “Oxford is engaged with Italian Advent-Irbm to test a vaccine on 500 volunteers in the UK.”
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Piero Di Lorenzo, CEO of Irbm: «If the vaccine proves to be effective, subject to the approval of the international control authorities, production should go into production at the end of September; a single producer cannot face the global scale. For this reason, an agreement was signed with the multinational AstraZeneca “. More in detail: after the positive results already obtained in the laboratory and in the monkeys, tests were carried out on 550 centers in England from April 23 on 550 volunteers healthy and another 500 who will receive a placebo solution. In January, good news will come, according to Di Lorenzo, the first doses will be ready.
IN DEEP
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The headquarters of the three Roman companies.
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Change of scenery, Hospital Spallanzani. Here human trials will begin in June (initially talked about July, but the stages are burning). The Lazio Region has contributed funding of 5 million euros, there is also a fundraiser on the Spallanzani website where they explain: “If the first tests give a positive result, they will lead to the administration of the vaccine in 2021 in a high number of people at risk ». In this case, the biotechnology company that developed the vaccine is based in Castel Romano (territory of Rome, on the border with Pomezia), it is called ReiThera, it has 80 employees, and in these laboratories, you can read on the website of the company, also worked on the Ebola vaccine. Stefano Colloca is responsible for technological development, Antonella Folgori, the CEO. A few weeks ago, when mouse experimentation was still underway, he explained: “From preclinical testing, we have a total antibody response. The target is the Spike protein, which the SarsCov2 coronavirus uses to attack human cells. The latter’s genetic sequence is carried by an animal virus, a harmless chimpanzee adenovirus and transformed into a shuttle. It is a preventive vaccine that, injected intramuscularly, would stimulate the production of antibodies and the activity of immune cells. “
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Another biotechnology company in the province of Rome., already at an advanced stage in vaccine research, is Takis, based in Pomezia. CEO Luigi Aurisicchio announced: “After a single vaccine, the mice developed antibodies that can block Sars-CoV-2 virus infection in human cells.” Takis focuses on the injection of a DNA fragment, followed by a brief electrical stimulus. Aurisicchio: «The technology is called electroporation and was developed in Italy. At Takis, we are already working on a process that can be changed in a few weeks, if the virus accumulates mutations and becomes invisible to the immune system. We are working hard: it is a vaccine that comes from Italian research, with completely Italian and innovative technology, we hope it will be tested in Italy and available to everyone. To do this, we need the support of institutions and partners to help us speed up the process. “For human trials, we are talking about September.
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Let’s be clear: it applies to the pharmaceutical center of Pomezia-Castel RomanoBut also for other projects around the world, the ads are sometimes used to raise funds (as it should be) and to date there is no certainty about the timing or effectiveness of any vaccine being studied. But the mobilization of science and industry has never been so massive in one goal. Many of the most important skills are found in the province of Rome, Frosinone and Latina. According to the Unindustria Study Center, Lazio exported 12.9 billion euros of pharmaceuticals in 2019, equivalent to 38 percent of the national total.
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