Vaccine, can I do the second dose with a different serum than the first?



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Different types of vaccinations anti-Covid but experts warn: they should not be mixed. Therefore, two doses of vaccinations different. Why should this happen? Because the vaccines used for the first dose may not be available for the second dose as well. So, in case of medicine shortage, what do you do?


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Vaccines at risk without the necessary doses

The problem is emerging, not without controversy, in England where the vaccination campaign with the first dose began. Pzifer and now the vaccine will come AstraZeneca. If you do not have a sufficient number of second doses in circulation PziferThe question is whether to drop coverage halfway or go ahead and try the vaccine mix route.

Different vaccines in circulation.

The vaccines used in this first phase in Great Britain are those of Pfizer-BioNTech, but from next week the AstraZeneca will also arrive. The doubt about their interchangeability arises precisely from the coexistence that will take place in a few days. But it should be noted that although both vaccines have two doses, they still work differently.

Mix different dosages? No, only in rare cases and at risk

According to UK government guidelines, published on December 31st, vaccine interchangeability is a ‘reasonable option, offering a locally available dose of the product to supplement the program is a preferred option if the individual is likely to be immediate high risk “.

However, experts shy away from the indication given by the guidelines. Dr. Mary Ramsay, head of vaccines for the Spanish public health, intervened on the issue to clarify, through CNN: “We do not recommend mixing vaccines for Covid-19, if the first dose is the vaccine Pfizer should not receive the vaccine AstraZeneca for the second dose and vice versa.

But Dr Ramsey also added that this is a viable route in rare emergency cases: ‘There may be extremely rare occasions when the same vaccine is not available or it is not known which vaccine the patient received. Every effort should be made to administer the same vaccine, but when this is not possible, it is better to administer a second dose of another vaccine rather than nothing ”.

From the dry America no to the drug mix

Scotland is following England’s lead, while Wales has already said it won’t. England, which is leading the way among Western countries in the vaccination campaign, is being questioned this time. The United States is clearly distancing itself from that choice, where experts emphasize the lack of safety evidence in the case of vaccine mixtures.

In fact, the warning comes from experts at the Centers for Disease Control and Prevention who have highlighted how the vaccines licensed so far are “not interchangeable with each other” and that “the safety and efficacy of a mixture have not been evaluated. of products”.

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