[ad_1]
Which is the best vaccine against Covid-19? AstraZeneca, Pfizer and Moderna are now in final sprint and vaccines may soon be available that can permanently eradicate the virus that has brought the entire world to its knees since last January.
In recent weeks there has been a series of information on the effectiveness and development of the different candidates that also made the scholarships dance. But what are the differences among the most popular vaccines and which is the most effective?
Pfizer, Modern and AstraZenaca Vaccine: Which is the Best?
The three vaccines are those that have reached more advanced phases of experimentation and presenting the best results at this time. But how effective are they? The candidate of Pfizer has shown to have a95% efficient against Covid-19 from the 28th day after the first administration. The tests were conducted on a total of approximately 43,500 people in six countries and the safety milestones required by the United States Food and Drug Administration (FDA) for Emergency Use Authorization (USA) have been reached.
The results on the efficacy of Modern reached a similar figure: based on preliminary data from phase 3, 30,000 participants enrolled in 100 clinical research centers in the United States the vaccine was found to work in 94.5% of cases. Finally, also the biopharmaceutical company AstraZeneca announced the first results (not yet published) showing a90% effective after administration of a reduced dose, ie half the dose during the first injection and a full dose after 4 weeks.
How Different Vaccines Work
A first substantial difference concerns the how different vaccines work. Pfizer me Modern have produced a solution that works in the same way, that is, it is based on what is called a RNA-type vaccine. Basically, with the injection of the vaccine, generic information is introduced into our organism, in the form of RNA, which activates the ribosomes, of particular organisms used to read genetic information, for the peak protein production of the coronavirus. This protein then activates an immune response This allows the body to produce antibodies capable of blocking infection in the event that we come into contact with the virus.
AstraZeneca instead, he opted for another type of vaccine, the traditional one. the classical method of vaccines actually provide for direct injection of the coronavirus spike protein. This is the call viral vector vaccine which uses a weakened version of a virus that has been genetically modified and therefore cannot infect humans. All three solutions have a double administration– A new injection should be given after approximately 28 days.
Storage temperatures
Another issue of fundamental importance for distribution, especially at the logistical level, is temperature and shelf life of the various solutions. In fact, as is now known, the Pfizer requires staying in a -70 degree temperature, and it seems that at the moment our country does not have adequate refrigerators. Only in the last few days, before injection, can Pfizer antidote be stored in normal refrigerators, for up to 5 days.
Vaccines Modern me AstraZeneca instead, they can be stored in more accessible temperatures, who prowl – 2 ° C to 8 ° C. According to some rumors, Moderna’s vaccine could also be kept at room temperature for several hours.
When will the doses be available?
Confirmation has arrived from Palazzo Chigi that the first doses of the vaccine (about 2 million) should arrive in Italy during the month of January and in the coming weeks we will begin to administer the antidotes on a voluntary basis. In June, however, a number of vials will arrive that will allowimmunization of about 30 million Italians, thanks to the different agreements signed by the European Union with the different pharmaceutical companies.
However, for the moment no dates set yet, but only forecasts. AstraZenaca in fact, it points to the production of approx. 500 million doses will be used for commercialization in Europe and the United Kingdom, the most ambitious project in Modern, which you think you can make available 3 billion doses by summer 2021. Pfizer instead, estimate a sun production 200 million dosesbound for the European Union, which in all probability will be the first to arrive.
How much will the different vaccines cost?
Also in the price of vaccines there are significant differences. It should be noted that the Government has already announced that the vaccination for citizens it will be full freeand the state will be responsible for the costs of vaccination.
At the moment the cheapest solution is AstaZeneca, which estimated a cost of only € 2.80 for each dose, while the vaccine Modern it will cost 22 €, finally that of Pfizer will come to me € 28, at the moment the most expensive.
