Stop the Johnson & Johnson vaccine trials. Side effects for a volunteer



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The American Pharmaceutical Company Johnson and Johnson has stopped testing its Covid vaccine. One of the 60,000 volunteers enrolled for the final testing phase had “an unexplained disorder.” The same happened on September 6 with the Anglo-Swedish firm AstraZeneca, which produces the Oxford vaccine and is currently testing 55,000 volunteers. Dosing resumed after a week, but not in the United States, where many of the 30,000 enrolled volunteers are still waiting for the second dose.

There are about 300 vaccines under study worldwide, about thirty are being tested in humans and about ten are in the final stages of testing. AstraZeneca me Johnson and Johnson they are among the most advanced. The second has the advantage of being able to be administered in a single dose, simplifying organizational problems. Considering the large number of volunteers involved, it is not unexpected to find adverse events, which could be independent of the vaccine. In these cases, an independent commission of doctors is created to assess whether the disorder is caused by immunization and whether it can be prevented. It is then decided whether to resume the experiments or to completely block the execution of the candidate vaccine.

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Longread

Gold Rush

The arrival of the first vaccines, expected in November with a good dose of optimism, could be postponed until the end of the year. As US President Donald Trump continues to announce the first injections in time for the elections (scheduled for November 3), the German Health Minister yesterday announced a more realistic agenda. Jens Spahn said that “as things are today, I think we can start in the first quarter of next year.” Also yesterday the United States government announced that it will finance AstraZeneca with 486 million dollars, to obtain 100,000 doses of monoclonal antibodies (not a vaccine, but a therapy under study) by the end of 2020 and another million in 2021.

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Deepening

Trump, Covid and the race for the electoral vaccine

Both of them AstraZeneca that of Johnson and Johnson They work by the method of the so-called viral vector. An adenovirus is injected into the body, a type of virus that is harmless and cannot replicate in our body. Adenovirus DNA had previously been modified in the laboratory. A gene sequence capable of inducing our cells to produce the peak protein (the tip of the crown) of the coronavirus was added. The spike, once in circulation in our body, stimulates the immune system and teaches it to recognize Sars-Cov-2. In case of infection with this virus, our defenses will be ready to jump to defeat it.


Greeting

Covid-19 vaccine, side effects in the United States

About your stop, Johnson and Johnson In a note, he explained that he wanted to protect the privacy of the person involved and that he had already set up the group of experts convened to evaluate the case, or Data security monitoring board (Dsmb). Given that half of the volunteers in a trial received a placebo, the first thing to check is whether the sick person actually received the candidate vaccine. Other pharmaceutical companies in an advanced stage of experimentation are the American Moderna and Pfizer, which have the problem of having to store and transport their vaccines at a temperature of -70ºC. The tests will tell us if the products are safe and boost the immune system. However, questions will remain about the effectiveness of immunization and its duration. The minimum goal is for vaccines to protect at least 50% of the people who receive them from infection and for the effect to last for a year. But it is possible that immunization reduces symptoms but not the possibility of infection or infection. So the lethality of Covid is reduced, but it is still necessary to keep masks and distances for a few more months.

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