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The breakthrough in treating Covid could come from a new study by a group of researchers from the Chinese Academy of Sciences, Shenzhen Institutes of Advanced Technology (SIAT): a drug that has been used to treat cancer for a decade could be useful in treating Covid-19 patients. This is the Bottle (pralatrexate) from Acrotech Biopharma, a chemotherapy drug developed and used in the treatment of lymphomas. The study found that it would be more effective than Remdesivir, the main antiviral drug used in patients with Sars-Cov-2. “Identifying effective drugs capable of treating Covid-19 is important and urgent, especially approved drugs that can be immediately tested in clinical trials,” said the study authors, led by Dr. Haiping zhang from Shenzhen Institutes of Advanced Technology – Our study found that pralatrexate is capable of potently inhibiting Sars-Cov-2 replication with stronger inhibitory activity than Remdesivir, under the same experimental conditions.
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A drug used for more than a decade to treat cancer could cure Covid-19 https://t.co/oPfZuFCJDd via @Online mail
– COVID-19 LiT (@ Covid19LiT) January 1, 2021
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To try to cope with the pandemic, researchers around the world searched for effective drugs and tested those that had already been approved to treat other diseases. Laboratory tests and trials were carried out to simulate how different drugs would interact once they came into contact with the new virus. Zhang and colleagues on his team conducted a virtual screening of existing drugs, reconstructing drug-virus interactions. They used this approach to examine 1,906 drugs, testing their potential to inhibit Sars-Cov-2 replication by targeting a viral protein called RdRP (RNA-dependent RNA polymerase), which essentially copies and replicates the genetic material of the virus. . Four promising drugs were identified, which were then tested in laboratory experiments. Two of the drugs, pralatrexate and azithromycin, successfully inhibited virus replication.
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Other laboratory experiments showed that pralatrexate was more effective than Remdesivir. However, the chemotherapy drug can cause significant side effects, and since it is used in the treatment of patients affected by a particularly aggressive form of lymphoma, immediate use is not guaranteed for those affected by Covid-19. However, the most important finding of the research is the efficacy of the experimental approach, with the screening strategy used to identify potentially useful drugs using artificial intelligence. The researchers, who have published their work in Computational Biology Plos, are now working on developing methods to generate molecular structures that could be exploited in new drugs for the treatment of Covid-19.
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Last updated: 13:45
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