[ad_1]
Problems with deliveries also for the Janssen vaccine pending approval from the European agency Ema? He dismisses them as “indiscretions that do not correspond to the truth”, Loredana Bergamini, Medical Director of Janssen Italia, the pharmaceutical division of Johnson & Johnson. “We are rigorously working on the logistics to get the batches to the place and when they need to be delivered.”
Other nasty surprises?
Our production schedule will allow us to meet the 200 million dose commitment for the EU in 2021. By the end of March we will have a more accurate picture of the supply schedule and we are in close contact with the Commission and the Member States. to define a more precise, regular and transparent delivery schedule. We expect the first batches to be available for the EU in the second quarter. We will distribute these volumes equally among all countries.
What are the characteristics of the vaccine?
«It is the only single dose that has concluded phase 3 of the trial, the final one. It is built on a platform in which we have an exclusive patent called AdVac that uses a cold adenovirus, designed to inactivate it and not be able to infect. Genetic information is inserted inside it, that of the Spike protein that Sars-CoV-2 uses to penetrate the human cell. Once inoculated, the cells read this information and stimulate the production of specific antibodies capable of responding to the coronavirus. ‘
Is it a new technology?
“No, Advac was also used to develop the Ebola vaccine, approved a year ago, and is currently being used to develop other candidate vaccines against Zika and AIDS. A proven technology, with a reassuring safety profile ”.
Where was the anti Covid developed?
“In the center of Leiden, in the Netherlands, the Janssen headquarters. Here is the largest production site. Aware of having to face a transcendental dose demand, other production centers have been activated worldwide where the finishing works will be carried out. The Italian Catalent is one of our partners and will take care of the packaging of the vials. ‘
And the effectiveness?
“Janssen’s preparation prevents in 85% of cases the most fearsome forms of Covid that require hospitalization and in 100% of cases it prevents death. That is why it has a very strong protection ».
How long after administration does immunity develop?
«From the seventh day the protection of antibodies begins. On the 28th it is 85% ».
Is it good for any age?
“In our experimental study we tested 45,000 people of all ages, from 18 to 60 years old. 41% of the volunteers enrolled had one or more chronic diseases: obesity, hypertension, diabetes, serious cardiovascular diseases. They all responded well. A study on children under 18 years of age and children is about to begin ”.
Does it work with variants?
“The vaccine was tested in South Africa and Brazil, where the variants were already circulating, and it worked.”
How is it preserved?
“The doses can be kept for two years at minus twenty degrees, once thawed they can remain at a temperature of 2 to 8 degrees for three months.”
Have you immediately concentrated into a single dose?
Yes, it was a strategic business choice. We realized that there was room for a one-time management plan. The possibility of avoiding the recall and of not having to return people for the second puncture in the emergency phase is a great advantage ”.
Price of 15 euros per dose?
“It is part of the agreements with the EU. For us it is a non-profit operation. We will not have an immediate return.
Side effects?
«The safety profile is excellent. Some lines of fever, for 1-2 days.
March 9, 2021 (change March 9, 2021 | 22:19)
© REPRODUCTION RESERVED
[ad_2]
