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He discovered the mechanism that triggers a severe inflammatory response in children with COVID-19. In a study published in the journal “Cell”, researchers from the children’s hospital Baby jesus from Rome – in collaboration with colleagues from the Karolinska Institutet in Stockholm, Sweden – shed light on a systemic inflammatory disease called Mis-C (Multisystemic Inflammatory Syndrome in Children), caused in children by the Sars-CoV2 coronavirus infection and initially mistaken for it Kawasaki disease. The work paves the way for specific tests for early diagnosis and specific treatments.
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At the beginning of the Sars-CoV2 pandemic, children seemed almost immune to the consequences of the new coronavirus. However, in the future, it has become clear that they too, albeit in a less severe way, could become ill with Covid-19 and, in some cases, develop a severe form of systemic inflammation: Mis-C, a new pathology that It can arise after contracting the Covid pathogen. Affected babies develop vasculitis (inflammation of the blood vessels), heart and bowel problems, and a systemic increase in inflammation.
New from us: The immunology of MIS-C against Kawasaki disease and acute COVID-19. Online now on mobile: https://t.co/Exln6uv3Av pic.twitter.com/XGEvP4QwRG
– Petter Brodin (@BrodinPetter) September 6, 2020
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Differences with Kawasaki syndrome
Features partly common to those of another vasculitis, Kawasaki disease, which initially suggested a causal link between Kawasaki and Sars-CoV2 infection. The study ‘Cactus – Immunological studies in children affected by Covid and acute diseases’ was developed by doctors and researchers from the Bambino Gesù during the health emergency to try to understand the Sars-CoV2 disease in children. The Covid Center of Palidoro, the General Pediatrics group that in recent years has been dedicated to the study of Kawasaki disease and the Clinical Immunology and Vaccination Department of the University Hospital’s Department of Pediatrics collaborated in the research.
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101 children participated, of which 13 with Covid who developed the multisystemic inflammatory form, 41 with Covid, 28 with Kawasaki disease that arose in the pre-Covid era and 19 healthy. In both diseases, Kawasaki and Mis-C – reports Capitoline Irccs – an alteration was detected in the levels of cytokines (mediators of inflammation) involved in the immune response, but with differences: for example interleukin 17a (IL-17a) increased particularly in children with Kawasaki disease, but not in those with Covid and Mis-C. Furthermore, compared to children with Kawasaki, in Covid patients who develop Mis-C, a high presence of autoantibodies has been identified, that is, antibodies directed against particular portions of heart tissue or substances from the body itself, which act against two specific proteins (endoglin and Rpbj). These autoantibodies can determine the typical vascular and cardiac damage of Mis-C.
Last updated: 13:32
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