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He discovered two super antibodies that block the entrance to the virus Sars-Cov-2 in cells: they act with slightly different mechanisms and if given in small doses, individually or together, they can prevent infection in mice. The result, which paves the way for new therapies based on antibody cocktails (also useful against mutant viruses), is published in Science by an international group led by the University of Washington, in which Massimo Galli, Agostino Riva and Arianna Gabrieli del Sacco Hospital in Milan.
Flu, that’s why you have to get vaccinated: the message of virologists and infectious diseases
Scientists studying monoclonal antibodies (mAbs) bounce back # COVID-19 patients report two, with different mechanisms of action, which together block # SARS-CoV-2 and mount a protective response in hamsters. Results support therapies involving combinations of mAbs https://t.co/jQ7T0G5ssr pic.twitter.com/wHteVMCj5U
– Science Magazine (@ScienceMagazine) September 29, 2020
“Mixtures including S2M11, S2E12, or the previously identified S309 antibody largely neutralize a panel of circulating SARS-CoV-2 isolates and activate effector functions,” the Science study reads. “Our results pave the way for the implementation of antibody cocktails for prophylaxis or therapy, avoiding or limiting the occurrence of viral escape mutants.”
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